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| CAS No.: | 24345-16-2 |
|---|---|
| Name: | Apamin |
| Molecular Structure: | |
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| Formula: | C79H131 N31 O24 S4 |
| Molecular Weight: | 2027.65 |
| Synonyms: | 66: PN: WO2008088422 FIGURE: 8 claimed protein;68: PN:WO2006116156 SEQID: 68 claimed protein;Apamin (reduced), cyclic (1?;15)-bis(disulfide);Apamine;L-Histidinamide,L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-a-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-,cyclic (1?;15)-bis(disulfide); |
| EINECS: | 246-182-7 |
| Density: | 1.63 |
| Boiling Point: | 847.17°C (rough estimate) |
| Safety: | Poison by intravenous, parenteral, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx. |
| PSA: | 1021.52000 |
| LogP: | -0.31540 |
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Chemistry
Molecular Formula: C79H131O24S4
Molecular Weight: 2027.65g/mol
EINECS: 246-182-7
Freely Rotating Bonds: 38
Polar Surface Area: 1021.52 Å2
Index of Refraction: 1.724
Molar Refractivity: 491.235 cm3
Molar Volume: 1238.918 cm3
Polarizability: 194.741× 10-24cm3
Surface Tension: 77.455 dyne/cm
Density: 1.636 g/cm3
The Cas Register Number of Apamin is 24345-16-2 .The chemical synonyms of Apamin (CAS No.24345-16-2) are H-+cys-asn-++cys-lys-ala-pro-glu-thr-ala-leu-+cys-ala-arg-arg-++cys-gln-gln- his-nh2 ; H-Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 ; H-Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 (disulfide bridge: 1-11, 3-15) ; Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 ; Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-cys-gln-gln-his-nh2 ; [Cys-asn-(cys-lys-ala-pro-glu-thr-ala-leu-cys]cycl-ala-arg-arg-cys)cycl-gln-gln-his-nh2 ; Cnckapetalcarrcqqh-nh2 ; Cnckapetalcarrcqqh-nh2 (disulfide bridge: 1-11,3-15) .Product categories of Apamin (CAS No.24345-16-2) are Peptide ; Beevoltage-gated ion channels ; Cell signaling and neuroscience ; Ion channel modulating peptides ; Monovalent ion channels ; Potassium channel modulators ; Potassium channel modulatorspeptides for cell biology ; Toxins and venoms ; Potassium channel .The molecular structure of Apamin (CAS No.24345-16-2) is
.
Uses
It can be used in organic synthesis.
Toxicity Data With Reference
| 1. | ipr-mus LD50:3800 µg/kg | TOXIA6 Toxicon. 22 (1984),308. | ||
| 2. | ivn-mus LD50:4 mg/kg | NSAPCC Naunyn-Schmiedeberg’s Archives of Pharmacology. 300 (1977),189. | ||
| 3. | ice-mus LD50:1800 ng/kg | TOXIA6 Toxicon. 22 (1984),308. | ||
| 4. | par-mus LD50:600 mg/kg | TOXIA6 Toxicon. 20 (1982),157. |
Safety Profile
Poison by intravenous, parenteral, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx.
Safety Statements: 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
RIDADR: 2811
WGK Germany: 3
RTECS: CD6899900
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III