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Apamin
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Name

Apamin

 EINECS 246-182-7
CAS No. 24345-16-2 Density 1.63
PSA 1021.52000 LogP -0.31540
Solubility N/A Melting Point N/A
Formula C79H131 N31 O24 S4 Boiling Point 847.17°C (rough estimate)
Molecular Weight 2027.65 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Poison by intravenous, parenteral, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 24345-16-2 (Apamin) Hazard Symbols N/A
Synonyms

66: PN: WO2008088422 FIGURE: 8 claimed protein;68: PN:WO2006116156 SEQID: 68 claimed protein;Apamin (reduced), cyclic (1?;15)-bis(disulfide);Apamine;L-Histidinamide,L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-a-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-,cyclic (1?;15)-bis(disulfide);

 

Apamin Chemical Properties

Molecular Formula: C79H131O24S4
Molecular Weight: 2027.65g/mol
EINECS: 246-182-7
Freely Rotating Bonds: 38
Polar Surface Area: 1021.52 Å2
Index of Refraction: 1.724
Molar Refractivity: 491.235 cm3
Molar Volume: 1238.918 cm3
Polarizability: 194.741× 10-24cm3
Surface Tension: 77.455 dyne/cm
Density: 1.636 g/cm3 
The Cas Register Number of Apamin is 24345-16-2 .The chemical synonyms of Apamin (CAS No.24345-16-2) are H-+cys-asn-++cys-lys-ala-pro-glu-thr-ala-leu-+cys-ala-arg-arg-++cys-gln-gln- his-nh2 ; H-Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 ; H-Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 (disulfide bridge: 1-11, 3-15) ; Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 ; Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-cys-gln-gln-his-nh2 ; [Cys-asn-(cys-lys-ala-pro-glu-thr-ala-leu-cys]cycl-ala-arg-arg-cys)cycl-gln-gln-his-nh2 ; Cnckapetalcarrcqqh-nh2 ; Cnckapetalcarrcqqh-nh2 (disulfide bridge: 1-11,3-15) .Product categories of Apamin (CAS No.24345-16-2) are Peptide ; Beevoltage-gated ion channels ; Cell signaling and neuroscience ; Ion channel modulating peptides ; Monovalent ion channels ; Potassium channel modulators ; Potassium channel modulatorspeptides for cell biology ; Toxins and venoms ; Potassium channel .The molecular structure of Apamin (CAS No.24345-16-2) is.

Apamin Uses

It can be used in organic synthesis.

Apamin Toxicity Data With Reference

1.    

ipr-mus LD50:3800 µg/kg

     TOXIA6    Toxicon. 22 (1984),308.
2.    

ivn-mus LD50:4 mg/kg

     NSAPCC    Naunyn-Schmiedeberg’s Archives of Pharmacology. 300 (1977),189.
3.    

ice-mus LD50:1800 ng/kg

     TOXIA6    Toxicon. 22 (1984),308.
4.    

par-mus LD50:600 mg/kg

     TOXIA6    Toxicon. 20 (1982),157.

Apamin Safety Profile

Poison by intravenous, parenteral, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx.
Safety Statements: 22-24/25 
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes.
RIDADR: 2811
WGK Germany: 3
RTECS: CD6899900
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III

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