Welcome to LookChem.com Sign In|Join Free

Product Name

  • or
Home > Products > 

Apricitabine

  • Name Apricitabine
  • EINECSN/A
  • CAS No. 160707-69-7
  • Density1.73
  • PSA115.67000
  • LogP-0.01290
  • SolubilityN/A
  • Melting PointN/A
  • FormulaC8H11 N3 O3 S
  • Boiling Point475.4±55.0 °C(Predicted)
  • Molecular Weight229.26
  • Flash PointN/A
  • Transport InformationN/A
  • AppearanceN/A
  • Safety
  • Risk CodesN/A
  • Molecular Structure
    Molecular Structure of 160707-69-7 (Apricitabine)
  • Hazard SymbolsN/A
  • SynonymsN/A
  • Article Data14

Apricitabine Specification

1. Introduction of Apricitabine

Apricitabine is an analogue of cytidine. The IUPAC name of this chemical is 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]pyrimidin-2-one. Apricitabine belongs to cytidine. Apricitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI) against HIV.

2. Properties of Apricitabine

Physical properties about Apricitabine are:
(1)XLogP3-AA: -1.2; (2)H-Bond Donor: 2; (3)H-Bond Acceptor: 4; (4)Rotatable Bond Count: 2; (5)Tautomer Count: 3; (6)Exact Mass: 229.052112; (7)MonoIsotopic Mass: 229.052112; (8)Topological Polar Surface Area: 113; (9)Heavy Atom Count: 15; (10)Formal Charge: 0; (11)Complexity: 331; (12)Isotope Atom Count: 0; (13)Defined Atom Stereocenter Count: 2; (14)Undefined Atom Stereocenter Count: 0; (15)Defined Bond Stereocenter Count: 0; (16)Undefined Bond Stereocenter Count: 0; (17)Covalently-Bonded Unit Count: 1; (18)Feature 3D Acceptor Count: 3; (19)Feature 3D Donor Count: 3; (20)Feature 3D Ring Count: 2; (21)Effective Rotor Count: 3; (22)Conformer Sampling RMSD: 0.6; (23)CID Conformer Count: 16.

3. Structure Descriptors of Apricitabine

(1)InChI: InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m1/s1;
(2)InChIKey: InChIKey=RYMCFYKJDVMSIR-RNFRBKRXSA-N;
(3)Smiles: c1cn(c(=O)nc1N)[C@H]2CO[C@H](S2)CO.

4. Uses of Apricitabine

Apricitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI) against HIV. When comes to the drug Apricitabine, 1200 mg apricitabine per day reduced the viral load by up to 1.65 logs (45 fold) in a small, 10-day randomized controlled trial. It is structurally related to lamivudine and emtricitabine.

 

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 160707-69-7
Related Products

Hot Products

Post a RFQ