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Asparaginase

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Name

Asparaginase

EINECS 232-765-3
CAS No. 9015-68-3 Density
Solubility Melting Point
Formula Unspecified Boiling Point
Molecular Weight 295.35 Flash Point
Transport Information Appearance white powder
Safety Risk Codes T,Xn
Molecular Structure Molecular Structure of 9015-68-3 (Asparaginase) Hazard Symbols 61-42/43-63:;
Synonyms

Colaspase;Crasnitin;Crisantaspase;E.C. 3.5.1.1;Elspar;Erwinase;Kidrolase;L-Asnase;L-Asparaginase;L-Asparagine amidohydrolase;Leunase;MK 965;NSC 109229;Oncospar;a-Asparaginase;

 

Asparaginase Specification

Asparaginase is one kind of is also known as Crisantaspase. Its classification codes are: (1)Antineoplastic; (2)Antineoplastic Agents; (3)Drug / Therapeutic Agent; (4)Human Data; (5)Natural Product; (6)Reproductive Effect; (7)Tumor data. It is stable at common pressure and temperature, and it should be sealed and stored in a cool and dry place. Moreover, it should be protected from light. It is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. Escherichia Coli A.S.1.357, Glycine, Boric acid buffer and so on can be used to manufacture the Asparaginase.

Uses of  Asparaginase: Asparaginase can be used as a food processing aid to reduce the formation of acrylamide, a suspected carcinogen, in starchy food products. The product is obtained by the breeding of bacterium. Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. Asparaginases are naturally occurring enzymes expressed and produced by microorganisms. It can be used as a food processing aid, a drug or an enzyme.

When you are using Asparaginase, please be cautious about it as the following:
This chemical may cause sensitisation by inhalation and skin contact. Moreover, it may cause harm to the unborn child. It has a possible risk of harm to the unborn child. You should not breathe dust. When using it, you need wear suitable protective clothing, gloves and eye/face protection. It should be avoided exposure that you need obtain special instructions before use. In case of accident or if you feel unwell, you should seek medical advice immediately (show the label where possible).

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 227mg/kg (227mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Recent Results in Cancer Research. Vol. 33, Pg. 174, 1970.
child TDLo intramuscular 8145iu/kg/1W (8145iu/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS Cancer Vol. 34, Pg. 780, 1974.
dog LD50 intravenous 227mg/kg (227mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Recent Results in Cancer Research. Vol. 33, Pg. 174, 1970.
guinea pig LD50 intraperitoneal 11662mg/kg (11662mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
mouse LD50 intraperitoneal 334gm/kg (334000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
mouse LD50 intravenous 136gm/kg (136000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
mouse LD50 oral 5000ku/kg (5000000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 919, 1971.
mouse LD50 subcutaneous 345gm/kg (345000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rabbit LD50 intravenous 2273ug/kg (2.273mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rat LD50 intraperitoneal 8204mg/kg (8204mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rat LD50 intravenous 7568mg/kg (7568mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rat LD50 oral 7500ku/kg (7500000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 919, 1971.
rat LD50 subcutaneous 8204mg/kg (8204mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.

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