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| CAS No.: | 27589-33-9 |
|---|---|
| Name: | Azosemide |
| Molecular Structure: | |
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| Formula: | C12H11 Cl N6 O2 S2 |
| Molecular Weight: | 370.843 |
| Synonyms: | Benzenesulfonamide,2-chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]- (9CI); Sulfanilamide,2-chloro-5-(1H-tetrazol-5-yl)-N4-2-thenyl- (8CI);2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide;5-(4-Chloro-5-sulfamoyl-2-thenylaminophenyl)tetrazole; Azosemide; Diart;Diurapid; Luret; Ple 1053; SK 110; SK 110 (pharmaceutical) |
| EINECS: | 248-549-7 |
| Density: | 1.661g/cm3 |
| Melting Point: | 218-221° |
| Boiling Point: | 671.1°Cat760mmHg |
| Flash Point: | 359.6°C |
| Safety: | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx. |
| PSA: | 163.27000 |
| LogP: | 3.69520 |
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Chemistry
Chemical Name: Azosemide
IUPAC NAME: 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
CAS No.: 27589-33-9
EINECS: 248-549-7
Molecular Formula: C12H11ClN6O2S2
Molecular Weight: 370.84 g/mol
Density: 1.661 g/cm3
Flash Point: 359.6 °C
Boiling Point: 671.1 °C at 760 mmHg
Following is the structure of Azosemide (CAS No.27589-33-9):
The chemical synonymous of Azosemide (CAS No.27589-33-9) are 2-Chloro-5-(1H-Tetrazol-5-Yl)-4-((2-Thienylmethyl)Amino)-Benzenesulfonamid ; 2-Chloro-5-(1H-Tetrazol-5-Yl)-N(Sup4)-2-Thenyl-Sulfanilamid ; 2-Chloro-5-(1h-Tetrazol-5-Yl)-N(Sup4)-2-Thenylsulfanilamide ; 5-(4’-Chloro-5’-Sulfamoyl-2’-Thenylaminophenyl)-Tetrazole ; Azosemid ; Ple1053 ; Azosemide ; 2-Chloro-5-(1H-Tetrazol-5-Yl)-4-(2-Thenylamino)Benzenesulphonamide
Toxicity Data With Reference
| 1. | orl-rat LD50:2545 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666. | ||
| 2. | ipr-rat LD50:287 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666. | ||
| 3. | ivn-rat LD50:252 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666. | ||
| 4. | orl-mus LD50:6350 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666. | ||
| 5. | scu-mus LD50:762 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),666. |
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx.