1. Introduction of Bafetinib
Bafetinib is one kind of white crystalline powder. The IUPAC name of this chemical is called 4-[[(3S)-3-(Dimethylamino)pyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(5-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide. It belongs to the product category of APIs. Bafetinib is a substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate).

2. Properties of Bafetinib
Physical properties about Bafetinib are:
(1)ACD/LogP: 3.03; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 0.11; (4)ACD/LogD (pH 7.4): 1.58; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 4.19; (7)ACD/KOC (pH 5.5): 1.26; (8)ACD/KOC (pH 7.4): 37.50; (9)#H bond acceptors: 9; (10) #H bond donors: 2; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 99.17 Å²; (13)Index of Refraction: 1.64; (14)Molar Refractivity: 151.838 cm³; (15)Molar Volume: 421.274 cm³; (16)Polarizability: 60.193×10^-24cm³; (17)Surface Tension: 67.07 dyne/cm; (18)Density: 1.369 g/cm³.

3. Structure Descriptors of Bafetinib
(1) SMILES: Cc1ccc(cc1Nc2ncc(cn2)c3cncnc3)NC(=O)c4ccc(c(c4)C(F)(F)F)CN5CC[C@@H](C5)N(C)C
(2) InChI: InChI=1S/C30H31F3N8O/c1-19-4-7-24(11-27(19)39-29-36-14-23(15-37-29)22-12-34-18-35-13-22)38-28(42)20-5-6-21(26(10-20)30(31,32)33)16-41-9-8-25(17-41)40(2)3/h4-7,10-15,18,25H,8-9,16-17H2,1-3H3,(H,38,42)(H,36,37,39)/t25-/m0/s1
(3) InChIKey: ZOPBZHLJXQAQON-VWLOTQADSA-N

4. Uses of Bafetinib
Bafetinib was identified as highly potent Bcr-Abl kinase inhibitor. It will usually be packaged in 25Kg.