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| CAS No.: | 15301-48-1 |
|---|---|
| Name: | bezitramide |
| Molecular Structure: | |
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| Formula: | C31H32 N4 O2 |
| Molecular Weight: | 492.621 |
| Synonyms: | 2-Benzimidazolinone,1-[1-(3-cyano-3,3-diphenylpropyl)-4-piperidyl]-3-propionyl- (7CI,8CI);2H-Benzimidazol-2-one,1-[1-(3-cyano-3,3-diphenylpropyl)-4-piperidinyl]-1,3-dihydro-3-(1-oxopropyl)-(9CI);1-(3-Cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)-piperidine;1-[1-(3-Cyano-3,3-diphenylpropyl)-4-piperidyl]-3-propionyl-2-benzimidazolinone;Bezitramide; Burgodin; R 4845 |
| Density: | 1.217g/cm3 |
| Melting Point: | 145-149°; mp 124.5-126° |
| Boiling Point: | 670.6°Cat760mmHg |
| Flash Point: | 359.4°C |
| Safety: | Poison by ingestion. Caution: May be habit forming. This is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). When heated to decomposition it emits toxic fumes of NOx and CN−. |
| PSA: | 71.03000 |
| LogP: | 5.32798 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
IUPAC Name: 4-[4-(2-oxo-3-propanoylbenzimidazol-1-yl)piperidin-1-yl]-2,2-diphenylbutanenitrile
Synonyms of Bezitramide (CAS NO.15301-48-1): Bezitramide [INN:BAN:DCF] ; 5-24-02-00382 (Beilstein Handbook Reference) ; BRN 0905485 ; Bezitramida ; Bezitramida [INN-Spanish] ; Bezitramide ; Bezitramidum ; Bezitramidum [INN-Latin] ; Burgodin ; EINECS 239-335-4 ; R 4845 ; R-4845 ; UNII-3KXW0Y310I ; 1-(1-(3-Cyano-3,3-diphenylpropyl)-4-piperidyl)-3-propionyl-2-benzimidazolinone ; 1-(3-Cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)piperidine ; 2-Benzimidazolinone, 1-(1-(3-cyano-3,3-diphenylpropyl)-4-piperidyl)-3-propionyl- ; DEA No. 9800
CAS NO: 15301-48-1
Molecular Formula of Bezitramide (CAS NO.15301-48-1): C31H32N4O2
Molecular Weight: 492.6114
H bond acceptors: 6
H bond donors: 0
Freely Rotating Bonds: 7
Polar Surface Area: 67.65 Å2
Index of Refraction: 1.618
Molar Refractivity: 141.93 cm3
Molar Volume: 404.6 cm3
Surface Tension: 55.4 dyne/cm
Density of Bezitramide (CAS NO.15301-48-1): 1.217 g/cm3
Flash Point: 359.4 °C
Enthalpy of Vaporization: 98.54 kJ/mol
Boiling Point: 670.6 °C at 760 mmHg
Vapour Pressure: 7.56E-18 mmHg at 25°C
Molecular Structure:
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Uses
Bezitramide is used as narcotic analgesic.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 80mg/kg (80mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971. |
| guinea pig | LD50 | oral | 60400ug/kg (60.4mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971. |
| mouse | LD50 | oral | 2101mg/kg (2101mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971. |
| rat | LD50 | oral | 141mg/kg (141mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: REGIDITY | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971. |
Consensus Reports
Cyanide and its compounds are on the Community Right-To-Know List.
Safety Profile
Poison by ingestion. Caution: May be habit forming. This is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). When heated to decomposition it emits toxic fumes of NOx and CN−.