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Bipariden

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Name

Bipariden

EINECS 208-184-6
CAS No. 514-65-8 Density 1.105 g/cm3
PSA 23.47000 LogP 3.90030
Solubility water: 25.1 mg/L Melting Point 114 °C
Formula C21H29NO Boiling Point 462.1 °C at 760 mmHg
Molecular Weight 311.467 Flash Point 224.5 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 514-65-8 (Bipariden) Hazard Symbols N/A
Synonyms

1-Piperidinepropanol,a-5-norbornen-2-yl-a-phenyl- (6CI,7CI,8CI);Akineton;KL 373;a-(Bicyclo[2.2.1]hept-5-en-2-yl)-a-phenyl-1-piperidinopropanol;a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol;

Article Data 3

Bipariden Chemical Properties

IUPAC Name: 1-(6-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
Synonyms: 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol ;1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol ;1-Piperidinepropanol, alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl- ; 1-Piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl- ; 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl- ; 3-Piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol ; A-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol ; A-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol
Molecular Structure of Biperiden (CAS NO. 514-65-8) :
Molecular Formula of Biperiden (CAS NO. 514-65-8) : C21H29NO
Molecular Weight of Biperiden (CAS NO. 514-65-8) : 311.46
CAS NO: 514-65-8
EINECS: 208-184-6
Mol File: 514-65-8.mol
Melting point 114 ºC
Water solubility 25.1 mg/L
Index of Refraction: 1.582
Surface Tension: 46.9 dyne/cm
Density: 1.105 g/cm3
Flash Point: 224.5 °C
Enthalpy of Vaporization: 76.19 kJ/mol
Boiling Point: 462.1 °C at 760 mmHg
Vapour Pressure: 2.45E-09 mmHg at 25°C
Appearance: crystal.
Solubility: easily soluble in water, slightly soluble in ethanol, soluble in methanol
 

Bipariden Uses

 Biperiden (CAS NO. 514-65-8) is used for the anti-Parkinson drugs and antispasmodic drugs.

Bipariden Production

With cyclopentadiene as raw materials, first the synthesis with chlorethylene to get Chloro-bicyclo heptene, and then reaction with Magnesium and Ether, producing Magnesium chloride of bicyclo heptene, the last condensation with β-piperidine phenyl acetone,then  Biperiden (CAS NO. 514-65-8) is derived.

Bipariden Toxicity Data With Reference

1.    

orl-rat LD50:750 mg/kg

    NIIRDN    Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636.
2.    

orl-mus LD50:530 mg/kg

    NIIRDN    Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636.
3.    

ipr-mus LD50:161 mg/kg

    NIIRDN    Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636.
4.    

orl-dog LD50:340 mg/kg

    NIIRDN    Drugs in Japan. Ethical Drugs, 6th Edition 1982. 6 (1982),636.
5.    

scu-mus LD50:195 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 128 (1960),204.
6.    

ivn-mus LD50:56 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 128 (1960),204.

Bipariden Safety Profile

Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition, it emits toxic fumes of NOx.

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