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4-amino-6-chloronicotinaldehyde is a chemical compound with the molecular formula C6H5ClN2O. It is a derivative of nicotinaldehyde, characterized by a pyridine ring with an amino group at the 4 position and a chlorine atom at the 6 position. 4-amino-6-chloronicotinaldehyde is known for its potential medicinal properties and applications in various scientific and industrial fields.

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  • 1001756-21-3 Structure
  • Basic information

    1. Product Name: 4-amino-6-chloronicotinaldehyde
    2. Synonyms: 4-amino-6-chloronicotinaldehyde
    3. CAS NO:1001756-21-3
    4. Molecular Formula: C6H5ClN2O
    5. Molecular Weight: 156.5697
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1001756-21-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 379.0±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.442±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    8. Solubility: N/A
    9. PKA: 2.58±0.42(Predicted)
    10. CAS DataBase Reference: 4-amino-6-chloronicotinaldehyde(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-amino-6-chloronicotinaldehyde(1001756-21-3)
    12. EPA Substance Registry System: 4-amino-6-chloronicotinaldehyde(1001756-21-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1001756-21-3(Hazardous Substances Data)

1001756-21-3 Usage

Uses

Used in Pharmaceutical Research:
4-amino-6-chloronicotinaldehyde is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used as an Anti-tuberculosis Agent:
In the field of medicinal chemistry, 4-amino-6-chloronicotinaldehyde is studied for its potential as an anti-tuberculosis agent. Its ability to target and inhibit the growth of Mycobacterium tuberculosis, the causative agent of tuberculosis, makes it a promising candidate for the development of new anti-tuberculosis drugs.
Used in the Development of Fluorescent Probes for Biological Imaging:
4-amino-6-chloronicotinaldehyde has been investigated for its potential use in the development of fluorescent probes for biological imaging. Its fluorescent properties allow for the visualization and tracking of cellular processes, making it a valuable tool in the field of biochemistry and molecular biology.
Used in Antibacterial and Antifungal Applications:
Due to its inherent antibacterial and antifungal properties, 4-amino-6-chloronicotinaldehyde is used in various applications to combat microbial infections. It can be incorporated into pharmaceutical formulations, disinfectants, and other products to enhance their antimicrobial efficacy.
Used in Organic Synthesis:
In the field of organic synthesis, 4-amino-6-chloronicotinaldehyde serves as a versatile building block for the synthesis of a wide range of organic compounds. Its reactive functional groups enable various chemical transformations, making it a valuable component in the synthesis of complex organic molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 1001756-21-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,7,5 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1001756-21:
(9*1)+(8*0)+(7*0)+(6*1)+(5*7)+(4*5)+(3*6)+(2*2)+(1*1)=93
93 % 10 = 3
So 1001756-21-3 is a valid CAS Registry Number.
InChI:InChI=1S/C6H5ClN2O/c7-6-1-5(8)4(3-10)2-9-6/h1-3H,(H2,8,9)

1001756-21-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Amino-6-chloronicotinaldehyde

1.2 Other means of identification

Product number -
Other names 4-amino-6-chloropyridine-3-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1001756-21-3 SDS

1001756-21-3Relevant articles and documents

CHEMICAL COMPOUNDS AS H-PGDS INHIBITORS

-

, (2019/01/08)

A compound of formula (I) wherein R1, R2, R3, R4, X, Y, and A are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3- d ]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells

Henry, James R.,Kaufman, Michael D.,Peng, Sheng-Bin,Ahn, Yu Mi,Caldwell, Timothy M.,Vogeti, Lakshminarayana,Telikepalli, Hanumaiah,Lu, Wei-Ping,Hood, Molly M.,Rutkoski, Thomas J.,Smith, Bryan D.,Vogeti, Subha,Miller, David,Wise, Scott C.,Chun, Lawrence,Zhang, Xiaoyi,Zhang, Youyan,Kays, Lisa,Hipskind, Philip A.,Wrobleski, Aaron D.,Lobb, Karen L.,Clay, Julia M.,Cohen, Jeffrey D.,Walgren, Jennie L.,McCann, Denis,Patel, Phenil,Clawson, David K.,Guo, Sherry,Manglicmot, Danalyn,Groshong, Chris,Logan, Cheyenne,Starling, James J.,Flynn, Daniel L.

, p. 4165 - 4179 (2015/06/08)

The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have shown significant clinical efficac

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS

-

, (2015/09/23)

Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for

MULTIPLE KINASE PATHWAY INHIBITORS

-

, (2014/04/17)

Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.

RAF INHIBITOR COMPOUNDS

-

, (2013/09/26)

This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

1,6- AND 1,8-NAPHTHYRIDINES

-

, (2012/07/28)

Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.

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