100372-92-7

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-morpholin-4-yl-2-thioxoethanone
• Synonyms: 1-(4-methoxyphenyl)-2-morpholin-4-yl-2-thioxoethanone;Ethanone, 1-(4-methoxyphenyl)-2-(4-morpholinyl)-2-thioxo-
• CAS NO: 100372-92-7
• Molecular Formula: C₁₃H₁₅NO₃S
• Molecular Weight: 265.33
• Mol File: 100372-92-7.mol

Chemical Properties

• Melting Point: 122-124 °C
• Boiling Point: 417.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• PKA: 0.39±0.20(Predicted)
• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-morpholin-4-yl-2-thioxoethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-morpholin-4-yl-2-thioxoethanone(100372-92-7)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-morpholin-4-yl-2-thioxoethanone(100372-92-7)

Safety Data

• Hazardous Substances Data: 100372-92-7(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 42945-78-8 2-(4-methoxy-phenyl)-1-morpholin-4-yl-ethanethione 
• 16208-17-6 2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one 
• 20177-84-8 1-(4-methoxyphenyl)-2-[2-(4-methoxyphenyl)-2-oxo-ethylsulfanyl]-ethanone 
• 46318-58-5 4-methoxybenzoylnitromethane 
• 38316-05-1 1-(4-methoxy-phenyl)-2-nitro-ethanol 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Efficient Synthesis of α-Ketothioamides From α-Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant-Free Conditions

We have developed a practical, general protocol for denitration of readily available α-nitroketones with sulfur and amines to access a broad range of α-ketothioamides under mild conditions. Such a reaction proceeds under metal-, oxidant-, and catalyst-free conditions to provide synthetically useful α-ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α-ketothioamides which are rarely reported.

Methyl ketone break-and-rebuild: A strategy for full α-heterofunctionalization of acetophenones

The Willgerodt reaction under iron-catalyzed aerobic conditions was found to be an excellent tool for full α-heterofunctionalization of acetophenones with sulfur and amines. Via this break-and rebuild strategy, a wide range of thioglyoxamides was synthesi

Direct synthesis of α-ketothioamides from aryl methyl ketones and amines via I2-promoted sp3 C-H functionalization

A domino reaction that involves the formation of CS and C-N bonds in one process via sp3 C-H functionalization strategy has been developed. This reaction affords an efficient and direct method for the synthesis of α-ketothioamides from aryl met

Na2S-mediated thionation: An efficient access to secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines

The task of this paper is to provide an efficient process for synthesis of secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines using Na2S as an effective catalyst. A plausible role for Na2S in the reaction of arylglyoxals with primary amines is proposed.

Reactions of diphenacylaniline and diphenacyl sulfide under Gewald conditions: Generation of enamines and thioamides

The 1,5-diketone, diphenacylaniline, yielded an enamine under Gewald conditions, while another 1,5-diketone, diphenacyl sulfide, resulted in thioamide formation under identical conditions. 2-Amino-4-(3-oxo-1,3- diphenylpropyl)-4,5,6,7-tetrahydrobenzo[b]th

Synthesis of α-ketothioamides via willgerodt-kindler reaction of arylglyoxals with amines and sulfur under solvent-free conditions

Willgerodt-Kindler reaction of arylglyoxal hydrates with secondary amines and elemental sulfur under solvent-free conditions at 80 °C is developed, in which α-ketothioamides are obtained in 70-90% yield in 0.6-1 hour. The X-ray crystal-structure analysis for one compound was obtained. Georg Thieme Verlag Stuttgart . New York.

A facile aerobic copper-catalyzed α-oxygenation of aryl thioacetamides: An efficient access to α-keto aryl thioamides

Copper(II) efficiently catalyzes the aerobic oxidation of aryl thioacetamides into the corresponding α-keto aryl thioamides in moderate to high yields in the presence of K2CO3 under O 2 atmosphere. This protocol is simple, clean, and generates water as the only byproduct. A mechanism is proposed for the reaction course. Georg Thieme Verlag Stuttgart.