100483-39-4Relevant articles and documents
DL-p-methylsulfonylphenyl serine ethyl ester preparation method
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Paragraph 0020-0038, (2020/02/29)
The invention discloses a DL-p-methylsulfonylphenyl serine ethyl ester preparation method, which comprises: 1) adding glycine ethyl ester hydrochloride into ethanol, and carrying out heating reflux; 2) dissolving basic cupric carbonate in ammonia water, and adding into the solution obtained in the step 1); 3) adding KOH into the solution obtained in the step 2) to adjust the pH value of the solution, and adding p-methylsulphonyl benzaldehyde, carrying out a reaction; and 4) after the reaction is finished, recovering ethanol in the reacted substance, adding ammonia water into the residue, regulating the pH value, cooling the solution, filtering, washing with ice water, and drying to obtain the p-methylsulfonylphenyl serine ethyl ester. According to the invention, the target product is generated by carrying out a one-step reaction on glycine ethyl ester hydrochloride and p-methylsulphonyl benzaldehyde under the catalysis of basic cupric carbonate and an alkali, wherein the reaction process does not require the use of concentrated sulfuric acid so as to completely avoid the generation of strong acid wastewater, protect and the environment, avoid the possible danger in the sulfuric acid transportation and production process, achieve the safety and easily improve the operation efficiency.
Synthesis method of D-p-methylsulfonylphenyl serine ethyl ester
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Paragraph 0008-0009, (2020/01/25)
The invention discloses a synthesis method of D-p-methylsulfonyl phenyl serine ethyl ester. The method comprises the following steps: preparing p-methylsulfonylphenylserine copper by taking p-methylsulfonylbenzaldehyde, copper sulfate and glycine as main raw materials; then adding anhydrous ethanol and concentrated sulfuric acid into an esterification reaction kettle, carrying out heating for a reaction, filtering out copper sulfate while the solution is hot, carrying out cooling for crystallizing, and carrying out filtering to obtain DL p-methylsulfonylphenyl serine ethyl ester sulfate, dissolving the DL p-methylsulfonylphenyl serine ethyl ester sulfate into water, removing copper ions by using a saturated sodium sulfide solution, adding an alkali into the mother solution for dissociationto obtain DL p-methylsulfonylphenyl serine ethyl ester, and adding a resolving agent for resolving to obtain a product. The method is simple in process, high in yield, low in cost and small in environmental pollution and is suitable for enterprise production.
P-Methyl sulfone phenyl ethyl serinate and synthetic method thereof
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Paragraph 0017; 0040; 0045-0059, (2018/09/12)
The invention discloses a synthetic method of P-methyl sulfone phenyl ethyl serinate, comprising the steps of S1, adding ethyl glycinate hydrochloride into methanol, and heating to dissolve to form afirst solution; S2, adding copper sulfate pentahydrate in the first solution to form a second solution by dissolving; S3, adjusting PH value of the second solution to meet the condition for alkaline reaction, adding P-methylsufonyl benzaldehyde to allow reaction, and holding the temperature and controlling the PH value to keep reaction condition values during reaction; S4, recycling methanol in the reacted materials, adding water to the residue to form a third solution, cooling, and centrifugally separating to obtain P-methyl sulfone phenyl ethyl serinate. The ethyl glycinate hydrochloride andP-methylsufonyl benzaldehyde are subjected to further reaction under the catalytic action of copper sulfate and an organic base to generate a target product; no sulfuric acid is used in the reactionprocess, the amount of waste acid in waste water is decreased, and the environment is protected; dangers that may occur during sulfuric acid transport and production are avoided, better safety is provided, and operating efficiency can be improved.
