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1006890-01-2

7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline is a complex organic compound with a unique molecular structure that features a quinazoline core, a methoxy group, a pyridine ring, and a quinoline-containing ethoxy side chain. 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline has been identified as a potent and selective inhibitor of phosphodiesterase 10A (PDE10A), a key enzyme involved in the regulation of cognitive and emotional processes in the brain.

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  • 1006890-01-2 Structure

  • Basic information

    1. Product Name: 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline
    2. Synonyms: 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline;7-Methoxy-4-(pyridin-3-yl)-6-[2-(quinolin-2-yl)ethoxy]quinazoline
    3. CAS NO:1006890-01-2
    4. Molecular Formula: C25H20N4O2
    5. Molecular Weight: 408.4519
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 1006890-01-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline(1006890-01-2)
    11. EPA Substance Registry System: 7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline(1006890-01-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1006890-01-2(Hazardous Substances Data)

1006890-01-2 Usage

Uses

Used in Pharmaceutical Industry:
7-Methoxy-4-(3-pyridinyl)-6-[2-(2-quinolinyl)ethoxy]quinazoline is used as a PDE10A inhibitor for the treatment of schizophrenia. Its potent and selective action on PDE10A makes it a promising candidate for the development of novel therapeutic agents to address the cognitive and negative symptoms associated with schizophrenia. By modulating the activity of PDE10A, this compound may help improve the overall functioning and quality of life for individuals living with this mental health disorder.

Check Digit Verification of cas no

The CAS Registry Mumber 1006890-01-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,6,8,9 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1006890-01:
(9*1)+(8*0)+(7*0)+(6*6)+(5*8)+(4*9)+(3*0)+(2*0)+(1*1)=122
122 % 10 = 2
So 1006890-01-2 is a valid CAS Registry Number.

1006890-01-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Methoxy-4-(pyridin-3-yl)-6-[2-(quinolin-2-yl)ethoxy]quinazoline

1.2 Other means of identification

Product number -
Other names 7-methoxy-4-pyridin-3-yl-6-(2-quinolin-2-ylethoxy)quinazoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1006890-01-2 SDS

1006890-01-2Downstream Products

1006890-01-2Relevant articles and documents

Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia

Helal, Christopher J.,Kang, Zhijun,Hou, Xinjun,Pandit, Jayvardhan,Chappie, Thomas A.,Humphrey, John M.,Marr, Eric S.,Fennell, Kimberly F.,Chenard, Lois K.,Fox, Carol,Schmidt, Christopher J.,Williams, Robert D.,Chapin, Douglas S.,Siuciak, Judith,Lebel, Lorraine,Menniti, Frank,Cianfrogna, Julia,Fonseca, Kari R.,Nelson, Frederick R.,O Connor, Rebecca,MacDougall, Mary,McDowell, Laura,Liras, Spiros

, p. 4536 - 4547 (2011/09/16)

Utilizing structure-based virtual library design and scoring, a novel chimeric series of phosphodiesterase 10A (PDE10A) inhibitors was discovered by synergizing binding site interactions and ADME properties of two chemotypes. Virtual libraries were docked and scored for potential binding ability, followed by visual inspection to prioritize analogs for parallel and directed synthesis. The process yielded highly potent and selective compounds such as 16. New X-ray cocrystal structures enabled rational design of substituents that resulted in the successful optimization of physical properties to produce in vivo activity and to modulate microsomal clearance and permeability.

HETEROAROMATIC QUINOLINE-BASED COMPOUNDS

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Page/Page column 26; 30, (2010/11/30)

The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.

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