100981-80-4

Basic information

• Product Name: CAPE
• Synonyms: (E)-3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID, 2-PHENYLETHYL ESTER;CAFFEIC ACID PHENYLETHYL ESTER;PHENYLETHYL CAFFEATE;PHENETHYL 3,4-DIHYDROXYCINNAMATE
• CAS NO: 100981-80-4
• Molecular Formula: C₁₅H₁₄O₄
• Molecular Weight: 284.31
• Mol File: 100981-80-4.mol

Chemical Properties

• Boiling Point: 470.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.282±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.03±0.20(Predicted)
• CAS DataBase Reference: CAPE(CAS DataBase Reference)
• NIST Chemistry Reference: CAPE(100981-80-4)
• EPA Substance Registry System: CAPE(100981-80-4)

Safety Data

• Hazardous Substances Data: 100981-80-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
CAPE is used as an antioxidant for its ability to protect cells from oxidative stress, which is a common factor in many diseases.
Used in Anti-Inflammatory Applications:
CAPE is used as an anti-inflammatory agent to reduce inflammation, a response that can contribute to various health conditions.
Used in Anticancer Applications:
CAPE is used as an anticancer agent to inhibit the growth of cancer cells, making it a potential therapeutic option for cancer treatment.
Used in Neurodegenerative Disorders Treatment:
CAPE is used as a neuroprotective agent for its potential to treat neurodegenerative disorders, possibly due to its antioxidant and anti-inflammatory properties.
Used in Cardiovascular Disease Management:
CAPE is used in the management of cardiovascular diseases, potentially due to its ability to reduce inflammation and oxidative stress, which are risk factors for such conditions.
Used in Diabetes Treatment:
CAPE is used in the treatment of diabetes, where its anti-inflammatory and antioxidant properties may help manage the disease and its complications.

Upstream product

• 99-50-3 3,4-Dihydroxybenzoic acid 
• 58534-64-8 3,4-Diacetoxy-benzoesaeure 
• 1425795-75-0 phenethyl-3,4-diacetoxybenzoate 
• 60-12-8 2-phenylethanol 
• 103-63-9 1-phenyl-2-bromoethane 

Related news

A CAPE (cas 100981-80-4) Cod model for the exponential dispersion family08/20/2019

The defining feature of the Cape Cod algorithm in current literature is its assumption of a constant loss ratio over accident periods. This is a highly simplifying assumption relative to the chain ladder model which, in effect, allows loss ratio to vary freely over accident period.Much of the li...detailed

Planning for water resilience: Competing agendas among CAPE (cas 100981-80-4) Town’s planners and water managers08/19/2019

Facing acute water challenges, the City of Cape Town has to reconcile the goal of building resilience to increasingly pronounced climate change impacts, including drought, with the persistent need to deliver equitable services and to achieve socially and environmentally just outcomes. In so doin...detailed

The transport of PM10 over CAPE (cas 100981-80-4) Town during high pollution episodes08/17/2019

This study investigates the influence of PM10 from remote sources on PM10 episodes over the city of Cape Town. For the study, we analysed observation data from Cape Town's air quality monitoring stations as well as high-resolution simulation data from the Weather Research and Forecasting mo...detailed

Provenance of CAPE (cas 100981-80-4) Supergroup sediments and timing of CAPE (cas 100981-80-4) Fold Belt orogenesis: Constraints from high-precision 40Ar/39Ar dating of muscovite08/16/2019

The Permian Cape Fold Belt (CFB) of South Africa forms part of a major orogenic belt that originally extended from Argentina, across southern Africa and into Antarctica. The CFB is dominated by complexly folded and faulted rocks of the siliciclastic Cape Supergroup that were deposited in the Cap...detailed

Relevant articles and documents

Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure–activity relationship

Given the hepatotoxicity and an unfavorable pharmacokinetic profile of zileuton (Zyflo), currently the only approved and clinically used 5-Lipoxygenase (5-LO) inhibitor, the search for potent and safe 5-LO inhibitors is highly demanded. The action of several phenolic acid phenethyl esters as potential 5-Lipoxygenase (5-LO) inhibitors has been investigated. For this purpose, a series of 14 phenethyl esters was synthesized and their impact on 5-LO inhibition was evaluated. The effects of position and number of hydroxyl and methoxy groups on the phenolic acid were investigated. The shortening of the linker between the carbonyl and the catechol moiety as well as the presence of the α,β-unsaturated carbonyl group was also explored. The sinapic acid phenethyl ester (10), which can be named SAPE (10) by analogy to caffeic acid phenethyl ester (CAPE), inhibited 5-LO in a concentration-dependent manner and outperformed both zileuton (1) and CAPE (2). With an IC50 of 0.3?μm, SAPE (10) was threefold more potent than CAPE (2) and 10-fold more potent than zileuton (1), the only 5-LO inhibitor approved for clinical use. Unlike CAPE (2), SAPE (10) had no effect on 12-lipoxygenase (12-LO) and less effect on cyclooxygenase 1 (COX-1) which makes it a more selective 5-LO inhibitor.

Design of antibacterial agents: Alkyl dihydroxybenzoates against xanthomonas citri subsp. citri

Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 μM), 16 (80 μM) and 28 (88 μM). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker.

Synthesis and antiradical/antioxidant activities of caffeic acid phenethyl ester and its related propionic, acetic, and benzoic acid analogues

Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.