- New NO donors with antithrombotic and vasodilating activities, part 22: Nitrosation products of hexamethylenetetramine
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Two nitrosation products of hexamethylenetetramine, namely 1,3,5- trinitrosohexahydro-1,3,5-triazine (1) and 3,7-dinitroso-1,3,5,7- tetrazabicyclo[3.3.1]nonane (2), were synthesized. It is shown that both compounds in vitro a 37 °C (1 h, pH 7.4) form nitric oxide at a rate of 3.1% (1) or 1.3% (2), respectively. In rats (60 mg/kg p.o.) both compound inhibit thrombus formation in arterioles (1: 20%; 2: 16%) and venules (1. 18%; 2. 9%). Compound 2 does not influence the blood pressure in spontaneously hypertensive rats.
- Herpel, Martin,Rehse, Klaus
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- Identifying urotropine derivatives as co-donors of formaldehyde and nitric oxide for improving antitumor therapy
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A pharmacophore integration strategy was utilized to develop the first co-donor of formaldehyde and nitric oxide (FANO), composed of urotropine derived nitramine/nitrosamine. FANO simultaneously generated formaldehyde and nitric oxide on-demand, resulting in synergistic anticancer effects. Importantly, liposomal formulation of FANO effectively inhibited tumor growth with minimal side-effects, providing a potent combined nitric oxide therapy for malignancy.
- Feng, Shujun,Luo, Jun,Meng, Xia,Ning, Xinghai,Xu, Yurui,Zhang, Yu
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p. 7581 - 7584
(2021/08/05)
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