10105-37-0Relevant articles and documents
A microwave improvement in the synthesis of the quinazoline scaffold
Chilin, Adriana,Marzaro, Giovanni,Zanatta, Samuele,Guiotto, Adriano
, p. 3229 - 3231 (2007)
A rapid and efficient microwave-assisted protocol is described that greatly improves a recent synthetic method developed for quinazoline synthesis. The synthetic protocol is based on the use of cycles of microwave irradiation. The optimization process is reported and the experimental results are compared with those of the conventional synthetic route.
A new access to quinazolines from simple anilines
Chilin, Adriana,Marzaro, Giovanni,Zanatta, Samuele,Barbieri, Vera,Pastorini, Giovanni,Manzini, Paolo,Guiotto, Adriano
, p. 12351 - 12356 (2007/10/03)
A new synthetic pathway to quinazolines is described. This new method uses hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH, starting from simple N-protected anilines. The method affords substituted quinazolines with high