- First synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine
-
The 2,2-difluorobenzodioxole moiety has been introduced in medicinal chemistry research as a potential metabolically more stable derivative of the benzodioxole fragment. Herein we present, to the best of our knowledge, the first synthesis of 4-chloro-2,2-
- Catalani, Maria Pia,Paio, Alfredo,Perugini, Lorenzo
-
-
Read Online
- FUNGAL CELL WALL SYNTHESIS GENE
-
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
- -
-
-
- Syntheses of Hydroxylated Bipyridines, I. - Orellanine, the Poison of a Toadstool
-
Two syntheses of orellanine, -3,3',4,4'-tetrol-1,1'-dioxide (5b), are developed which comprise 10 or 11 steps, respectively.The chemical reactions of 5b with diazomethane and on UV irradiation are described.
- Dehmlow, Eckehard V.,Schulz, Hans-Joachim
-
p. 857 - 862
(2007/10/02)
-
- SYNTHESIS OF ORELLANINE, THE LETHAL POISON OF A TOADSTOOL
-
A ten step synthesis of the structure of orellanine, 3,3',4,4'- hydroxy-2,2'-bipyridyl-bis-N-oxide (1a), is described which proves the identity of the natural product.
- Dehmlow, Eckehard, V.,Schulz, Hans-Joachim
-
p. 4903 - 4906
(2007/10/02)
-
