102236-25-9Relevant articles and documents
Kit for measuring calcium ions and use method thereof
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Paragraph 0053; 0063-0066, (2021/05/01)
The invention belongs to the technical field of analysis and detection, and particularly relates to a kit for measuring calcium ions and a using method thereof. The invention mainly relates to a kit for measuring calcium ions, which contains a compound as
A Comprehensive Study of the Ca2+ Ion Binding of Fluorescently Labelled BAPTA Analogues
Csomos, Attila,Kontra, Bence,Jancsó, Attila,Galbács, Gábor,Deme, Ruth,Kele, Zoltán,Rózsa, Balázs József,Kovács, Ervin,Mucsi, Zoltán
supporting information, p. 5248 - 5261 (2021/10/19)
Since its development, the ionophore BAPTA (1,2-bis(2-aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as “linker”). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the linker's length, the number of oxygen atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications.
METHODS FOR PREPARING FUEL ADDITIVES
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Page/Page column 34, (2019/07/17)
A method is provided for preparing a fuel additive having the formula: ( l ) The method comprises carrying out the following reactions: (i) addition of an alkylating agent b to starting material a: (a) to form an intermediate c; and (ii) ring closing intermediate c to form fuel additive e.
METHOD FOR MEASUREMENT OF CALCIUM IONS
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Paragraph 0072; 0073; 0074; 0075; 0076, (2016/10/17)
The present invention refers to calcium reagent for and said reagent relates to a measurement method. More in particular, mono-nitro substituted BAPTA-type chelator (BAPTA = 1, 2-bis (2-aminophenoxy) ethane-N, N, N ', N' -ethylenedaiminetetra acetic acid)
Structural study and fluorescent property of a novel organic microporous crystalline material
Cheng, Zhao,Yang, Bingqin,Yang, Meipan,Zhang, Binglin
, p. 112 - 118 (2014/02/14)
A novel microporous organic material [(2-{2-[2-(bis- methoxycarbonylmethylamino)phenoxy] ethoxy}-4-benzimidazole-phenyl) methoxycarbonylmethylamino]acetic acid methyl ester 6 was synthesized and characterized by single crystal X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), electron spray ionization-mass spectrometry (ESI-HRMS), X-ray powder diffraction (PXRD), 1H and 13C NMR. 6 crystallizes in the centrosymmetric monoclinic space group C2/c, with unit cell parameters a = 35.648(3) A?, b = 14.3240(12) A?, c = 15.3693(13) A?, α = 90.00, β = 94.8190(10),. = 90.00, V = 7820.16 A?3 and Z = 8 at 296(2) K. As indicated by crystal packing, the molecular conjugation planes arrange along the c axis to form micropores due to the hydrogen bonds. In addition, the fluorescent spectrum and luminescence lifetime were studied for 6.
Synthesis of new BAPTA calcium chelators
He, Huai Zhen,Lei, Lei,Li, Jian Li,Shi, Zhen
experimental part, p. 2074 - 2081 (2009/10/17)
A series of new 1,2-bis-(2-aminophenoxyethane) N,N,N',N'-tetraacetic acid (BAPTA) chelators were designed and synthesized to form novel and improved fluorescent indicators. Substituted 2-nitrophenol, acting as the material, reacted in five steps to give BAPTA-derived chelators. The Ca2+ affinity of BAPTA chelators could increase significantly by addition of electron-donating groups and decrease by electron-withdrawing groups. Compounds 3a-e were treated with iron powder instead of hydrogenation, obtaining a satisfying yield. The structures of all compounds were characterized by infrared, 1H NMR, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) spectra.
Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands
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Page/Page column 61, (2010/11/25)
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
CROWN ETHER DERIVATIVES
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Page/Page column 55, (2010/02/10)
The invention describes crown ether chelators, including crown ethers having the formula (A) or (B); and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na and K ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.
Reactive dyestuffs
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, (2008/06/13)
Triphendioxazine reactive dyestuffs of the general formula STR1 with the substituent definition given in the description, are outstandingly suitable for dyeing and printing materials containing hydroxyl groups or amide groups. They give red dyeings with high wet- and light-fastnesses.