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2-(2-Chloroethoxy)nitrobenzene is a chemical compound characterized by the molecular formula C8H8ClNO3. It is a nitro compound featuring a chloroethoxy group attached to the benzene ring, which endows it with unique chemical properties. 2-(2-Chloroethoxy)nitrobenzene is typically a yellow to brown liquid with a faint odor, and it exhibits solubility in organic solvents while being insoluble in water. Due to its potential harmful effects upon ingestion, inhalation, or skin contact, as well as its capacity to cause skin and eye irritation, it is classified as a potentially hazardous substance. Moreover, it is recognized as an environmental hazard, necessitating careful handling during its use and disposal.

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  • 102236-25-9 Structure
  • Basic information

    1. Product Name: 2-(2-CHLOROETHOXY)NITROBENZENE
    2. Synonyms: 2-(2-CHLOROETHOXY)NITROBENZENE;UKRORGSYN-BB BBV-1775312
    3. CAS NO:102236-25-9
    4. Molecular Formula: C8H8ClNO3
    5. Molecular Weight: 201.607
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 102236-25-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 322.4 °C at 760 mmHg
    3. Flash Point: 148.8 °C
    4. Appearance: /
    5. Density: 1.316 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(2-CHLOROETHOXY)NITROBENZENE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(2-CHLOROETHOXY)NITROBENZENE(102236-25-9)
    11. EPA Substance Registry System: 2-(2-CHLOROETHOXY)NITROBENZENE(102236-25-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 102236-25-9(Hazardous Substances Data)

102236-25-9 Usage

Uses

Used in Organic Synthesis:
2-(2-Chloroethoxy)nitrobenzene is utilized as a key intermediate in the synthesis of a variety of organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable component in the creation of new molecules with specific properties.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(2-Chloroethoxy)nitrobenzene is employed as a precursor in the development of drugs. Its reactivity and functional groups facilitate the production of pharmaceuticals with targeted therapeutic effects, contributing to the advancement of medicinal chemistry.
Used in Chemical Research:
2-(2-Chloroethoxy)nitrobenzene also serves as a model compound in chemical research, where it is used to study reaction mechanisms, explore new synthetic pathways, and understand the properties of related compounds. This research can lead to the discovery of novel applications and improvements in existing chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 102236-25-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,2,3 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 102236-25:
(8*1)+(7*0)+(6*2)+(5*2)+(4*3)+(3*6)+(2*2)+(1*5)=69
69 % 10 = 9
So 102236-25-9 is a valid CAS Registry Number.

102236-25-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-Chloroethoxy)-2-nitrobenzene

1.2 Other means of identification

Product number -
Other names MS-2654

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:102236-25-9 SDS

102236-25-9Relevant articles and documents

Kit for measuring calcium ions and use method thereof

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Paragraph 0053; 0063-0066, (2021/05/01)

The invention belongs to the technical field of analysis and detection, and particularly relates to a kit for measuring calcium ions and a using method thereof. The invention mainly relates to a kit for measuring calcium ions, which contains a compound as

A Comprehensive Study of the Ca2+ Ion Binding of Fluorescently Labelled BAPTA Analogues

Csomos, Attila,Kontra, Bence,Jancsó, Attila,Galbács, Gábor,Deme, Ruth,Kele, Zoltán,Rózsa, Balázs József,Kovács, Ervin,Mucsi, Zoltán

supporting information, p. 5248 - 5261 (2021/10/19)

Since its development, the ionophore BAPTA (1,2-bis(2-aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as “linker”). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the linker's length, the number of oxygen atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications.

METHODS FOR PREPARING FUEL ADDITIVES

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Page/Page column 34, (2019/07/17)

A method is provided for preparing a fuel additive having the formula: ( l ) The method comprises carrying out the following reactions: (i) addition of an alkylating agent b to starting material a: (a) to form an intermediate c; and (ii) ring closing intermediate c to form fuel additive e.

METHOD FOR MEASUREMENT OF CALCIUM IONS

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Paragraph 0072; 0073; 0074; 0075; 0076, (2016/10/17)

The present invention refers to calcium reagent for and said reagent relates to a measurement method. More in particular, mono-nitro substituted BAPTA-type chelator (BAPTA = 1, 2-bis (2-aminophenoxy) ethane-N, N, N ', N' -ethylenedaiminetetra acetic acid)

Structural study and fluorescent property of a novel organic microporous crystalline material

Cheng, Zhao,Yang, Bingqin,Yang, Meipan,Zhang, Binglin

, p. 112 - 118 (2014/02/14)

A novel microporous organic material [(2-{2-[2-(bis- methoxycarbonylmethylamino)phenoxy] ethoxy}-4-benzimidazole-phenyl) methoxycarbonylmethylamino]acetic acid methyl ester 6 was synthesized and characterized by single crystal X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), electron spray ionization-mass spectrometry (ESI-HRMS), X-ray powder diffraction (PXRD), 1H and 13C NMR. 6 crystallizes in the centrosymmetric monoclinic space group C2/c, with unit cell parameters a = 35.648(3) A?, b = 14.3240(12) A?, c = 15.3693(13) A?, α = 90.00, β = 94.8190(10),. = 90.00, V = 7820.16 A?3 and Z = 8 at 296(2) K. As indicated by crystal packing, the molecular conjugation planes arrange along the c axis to form micropores due to the hydrogen bonds. In addition, the fluorescent spectrum and luminescence lifetime were studied for 6.

Synthesis of new BAPTA calcium chelators

He, Huai Zhen,Lei, Lei,Li, Jian Li,Shi, Zhen

experimental part, p. 2074 - 2081 (2009/10/17)

A series of new 1,2-bis-(2-aminophenoxyethane) N,N,N',N'-tetraacetic acid (BAPTA) chelators were designed and synthesized to form novel and improved fluorescent indicators. Substituted 2-nitrophenol, acting as the material, reacted in five steps to give BAPTA-derived chelators. The Ca2+ affinity of BAPTA chelators could increase significantly by addition of electron-donating groups and decrease by electron-withdrawing groups. Compounds 3a-e were treated with iron powder instead of hydrogenation, obtaining a satisfying yield. The structures of all compounds were characterized by infrared, 1H NMR, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) spectra.

Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands

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Page/Page column 61, (2010/11/25)

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

CROWN ETHER DERIVATIVES

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Page/Page column 55, (2010/02/10)

The invention describes crown ether chelators, including crown ethers having the formula (A) or (B); and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na and K ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.

Reactive dyestuffs

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, (2008/06/13)

Triphendioxazine reactive dyestuffs of the general formula STR1 with the substituent definition given in the description, are outstandingly suitable for dyeing and printing materials containing hydroxyl groups or amide groups. They give red dyeings with high wet- and light-fastnesses.

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