96315-08-1

Usage

Uses

Used in Pharmaceutical Synthesis:
4-METHYL-1-NITRO-2-[2-(2-NITROPHENOXY)ETHOXY]-BENZENE is used as an intermediate in the synthesis of pharmaceutical compounds. Specifically, it is an impurity in the synthesis of 5-Methyl-bis-(2-aminophenoxymethylene)-N,N,N’,N’-tetraacetate Methyl Ester (M294140), a compound with potential therapeutic applications.
In the pharmaceutical industry, the synthesis of complex organic molecules often involves the formation of impurities that need to be controlled or removed to ensure the purity and efficacy of the final product. The presence of 4-METHYL-1-NITRO-2-[2-(2-NITROPHENOXY)ETHOXY]-BENZENE as an impurity in the synthesis of M294140 highlights the importance of monitoring and managing impurities during the drug development process.

InChI:InChI=1/C15H14N2O6/c1-11-6-7-13(17(20)21)15(10-11)23-9-8-22-14-5-3-2-4-12(14)16(18)19/h2-7,10H,8-9H2,1H3

Upstream product

• 700-38-9 2-nitro-5-methylphenol 
• 18800-37-8 1-(2-bromoethoxy)-2-nitrobenzene 
• 102236-25-9 1-(2-chloroethoxy)-2-nitrobenzene 
• 106-93-4 ethylene dibromide 
• 88-75-5 2-hydroxynitrobenzene 
• 96315-07-0 1-bromo-2-(2'-nitro-5'-methylphenoxy)ethane 

Downstream Products

• 96331-95-2 1-(2'-amino-5'-methylphenoxy)-2-(2''-aminophenoxy)ethane 
• 1310125-61-1 5-bromo-5'-methyl-BAPTA ethyl ester 
• 1337908-25-4 [allyloxycarbonylmethyl-(2-{2-[2-(bis-allyloxycarbonylmethylamino)-5-methyl-phenoxy]-ethoxy}-phenyl)-amino]-acetic acid allyl ester 
• 1337908-26-5 [allyloxycarbonylmethyl-(2-{2-[2-(bis-allyloxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-4-formyl-phenyl)-amino]-acetic acid allyl ester 
• 96315-10-5 N-(2-(2-(2-(bis(methoxycarbonylmethyl)amino)phenoxy)ethoxy)-4-methylphenyl)-N-(methoxycarbonylmethyl)aminoacetic acid methyl ester 
• 96315-09-2 5-methyl-BAPTA tetraethyl ester 

Relevant academic research and scientific papers

Kit for measuring calcium ions and use method thereof

The invention belongs to the technical field of analysis and detection, and particularly relates to a kit for measuring calcium ions and a using method thereof. The invention mainly relates to a kit for measuring calcium ions, which contains a compound as

CELL-PERMEABLE IMAGING SENSORS AND USES THEREOF

The disclosure relates in some aspects to imaging agents, and in particular, imaging agents for sensing of calcium signaling. According to some embodiments of the disclosure, contrast agents for magnetic resonance imaging and related technologies are prov

METHOD FOR MEASUREMENT OF CALCIUM IONS

The present invention refers to calcium reagent for and said reagent relates to a measurement method. More in particular, mono-nitro substituted BAPTA-type chelator (BAPTA = 1, 2-bis (2-aminophenoxy) ethane-N, N, N ', N' -ethylenedaiminetetra acetic acid)

Water-soluble, redox-active organometallic calcium chelators

This paper describes a new series of organometallic water-soluble chelators combining a redox moiety (ferrocene) and a selective Ca2+ chelator (BAPTA) separated by an ethynyl bridge. We report the synthesis and characterization of organometallic derivatives of the BAPTA chelator featuring one (2a) and two ferrocenyl (2b) moieties. Single crystal X-ray structural analysis on these chelators revealed unexpected conformations for the ferrocenyl substituent with respect to the phenyl ring of the BAPTA unit. DFT calculations on a model system of the ferrocenyl-ethynyl-BAPTA molecule were carried out to evaluate the energy separation between the two limiting conformations observed experimentally in the solid state, and to check the effective electronic communication between the binding pocket and the redox probe. The binding affinity of 2a-b for Ca2+, as probed by UV-Vis and cyclic voltammetry, revealed distinct behaviors in the presence of a metal ion depending on whether BAPTA is substituted by one or two ferrocenyl groups.

A near-infrared fluorescent calcium probe: A new tool for intracellular multicolour Ca2+ imaging

We report a novel near-infrared fluorescent calcium probe (KFCA), which has good optical properties such as intense NIR fluorescence emission (670 nm, QY: 0.24), excellent ON/OFF ratio (120-fold), and good wavelength-compatibility with visible-light-emissive fluorophores (Fluo-4, DsRed2), and which is applicable for real-time dual-colour intracellular Ca2+ imaging.

An organometallic derivative of a BAPTA ligand: Towards electrochemically controlled cation release in biocompatible media

The combination of a ferrocenyl moiety with BAPTA provides a novel, water-soluble, redox-active chelator. This chelator behaving as a conformational sensor exhibits an unexpected electrochemical response with high affinity and selectivity for calcium.

Two-photon excited fluorescent probes for calcium based on internal charge transfer

Two-photon excited (TPE) calcium fluorescent probes are designed and synthesized based on internal charge transfer (ICT) with high Ca2+ affinity and large two-photon action cross section, which can be used in living cells and detected with two-

Microsphere-based real-time calcium sensing

Sensing within the cell: Microspheres (2 μm) covalently loaded with calcium sensors can be delivered efficiently into living cells to analyze the intracellular changes in the concentration of Ca2+ ions in real time. The figure shows the real-ti

CROWN ETHER DERIVATIVES

The invention describes crown ether chelators, including crown ethers having the formula (A) or (B); and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na and K ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.

Crown ether derivatives

The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reactive group, a conjugated substance, or