51661-19-9

Usage

Chemical Properties

Yellow Crystalline Solid

InChI:InChI=1/C14H12N2O6/c17-15(18)11-5-1-3-7-13(11)21-9-10-22-14-8-4-2-6-12(14)16(19)20/h1-8H,9-10H2

Upstream product

• 1124-31-8 potassium 4-nitrophenolate 
• 106-93-4 ethylene dibromide 
• 824-39-5 sodium o-nitrophenate 
• 107-06-2 1,2-dichloro-ethane 
• 88-75-5 2-hydroxynitrobenzene 
• 107-04-0 1-Bromo-2-chloroethane 
• 102236-25-9 1-(2-chloroethoxy)-2-nitrobenzene 

Downstream Products

• 52411-34-4 1,2-Bis(2-aminophenoxy)ethane 
• 92061-47-7 1,2-bis-(2,4-dinitro-phenoxy)-ethane 
• 10112-15-9 N-Ethyl-2-nitroaniline 
• 612-28-2 2-nitro-N-methylaniline 
• 73630-07-6 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester 
• 475578-64-4 5,5’-diformyl-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic ethyl ester 
• 475578-63-3 5,5'-di(benzyliminomethyl)-BAPTA-tetraethyl ester 
• 85233-19-8 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid 
• 161554-96-7 C₁₆H₂₀N₂O₂ 
• 161555-00-6 2-{[2-(2-{2-[(2-Hydroxy-ethyl)-methyl-amino]-phenoxy}-ethoxy)-phenyl]-methyl-amino}-ethanol 
• 161554-98-9 2-[[2-(2-{2-[Bis-(2-hydroxy-ethyl)-amino]-phenoxy}-ethoxy)-phenyl]-(2-hydroxy-ethyl)-amino]-ethanol 
• 161554-93-4 [(2-{2-[2-(Ethoxycarbonylmethyl-methyl-amino)-phenoxy]-ethoxy}-phenyl)-methyl-amino]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of a [2.2.2] cryptand containing reactive functional groups

The functional group- containing potassium ionophore 195, 245 dibromo-4,7,13,16,20,23-hexaoxa-1,10 diaza-19(1,2), 24(1,2 dibenzabicyclo[8.8.6] tetracosaphane has been synthesized.

Hg2+-selective ratiometric and "off-on" chemosensor based on the azadiene-pyrene derivative

A new pyrene-based derivative bearing an azadiene group was synthesized as a ratiometric chemosensor for Hg2+ in aqueous acetonitrile solution. The "off-on" type signaling behavior of the fluoroionophore is due to the metal ion induced conformational changes from the weak pyrene monomer emissions to strong pyrene excimer emission.

Long-Term Tracking and Dynamically Quantifying of Reversible Changes of Extracellular Ca2+ in Multiple Brain Regions of Freely Moving Animals

Understanding physiological and pathological processes in the brain requires tracking the reversible changes in chemical signals with long-term stability. We developed a new anti-biofouling microfiber array to real-time quantify extracellular Ca2+ concentrations together with neuron activity across many regions in the mammalian brain for 60 days, in which the signal degradation was 2+ upon ischemia-reperfusion processes. The changing sequence and rate of Ca2+ in 7 brain regions were different during the stroke. ROS scavenger could protect Ca2+ influx and neuronal activity after stroke, suggesting the significant influence of ROS on Ca2+ overload and neuron death. We demonstrated this microarray is a versatile tool for investigating brain dynamic during pathological processes and drug treatment.

A Comprehensive Study of the Ca2+ Ion Binding of Fluorescently Labelled BAPTA Analogues

Since its development, the ionophore BAPTA (1,2-bis(2-aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as “linker”). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the linker's length, the number of oxygen atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications.

A Copper Nanocluster-Based Fluorescent Probe for Real-Time Imaging and Ratiometric Biosensing of Calcium Ions in Neurons

Fluorescent calcium ion (Ca2+) sensing and imaging have become an essential technique for investigation of signaling pathways of Ca2+ and understanding the role of Ca2+ in neurodegenerative disease. Herein a copper nanocluster (CuNC)-based ratiometric fluorescent probe was developed for real-time sensing and imaging of Ca2+ in neurons, in which a specific Ca2+ ligand with two formaldehyde groups was synthesized and further conjugated with polyethylenimine (PEI) to form a new ligand molecule for the synthesis of CuNCs. Meanwhile, water-soluble Alex Fluor 660 NHS ester was immobilized onto CuNCs as a reference element. The developed ratiometric fluorescence nanoprobe demonstrated a good linearity with Ca2+ concentration in the range of 2-350 μM, and a detection limit down to 220 ± 11 nM was achieved. In addition, the response time of the present probe for Ca2+ was found to be less than 2 s with good stability and high selectivity. Taking advantage of the low cytotoxicity and good biocompatibility of the developed nanoprobe, it was discovered that the histamine-induced cytoplasmic Ca2+ increase in various parts of neurons was different. Moreover, it was found O2--induced cytoplasmic Ca2+ burst and O2--induced neuronal death possibly resulted from Ca2+ overload in the neurons.

DISAZO　YELLOW PIGMENT, PIGMENTS DISPERSION AND PHOTOSENSITIVE RESIN COMPOSITION USING THE SAME

Novel pigment yellow formation of pigment dispersion including oh settlement compound and disclosure photosensitive resin composition are disclosed. Said discharge oh settlement compounds are high heat resistance and excellent dispersion property, the dispersion of pigment dispersion including same on the base and storage stability. The, said discharge oh settlement using the photosensitive resin compositions have a good coloring compounds including pigment dispersion can be implementing force, such as a high-quality color filter having an excellent optical brightness and contrast can be [...] number. (by machine translation)

[18F] Fluoride Cryptate Complexes for Radiolabeling Fluorinations

The present invention claims UV detectable (λ>210 nm) potassium [18F]fluoride diaryl- and aryl-fused [2.2.2]cryptate complexes suitable for performing radio-labeling reactions to generate [18F] fluorinated species.

[18F] fluoride cryptate complexes for radiolabeling fluorinations

The present invention claims UV detectable (λ>210 nm) potassium [18F]fluoride diaryl- and aryl-fused [2.2.2]cryptate complexes suitable for performing radio-labeling reactions to generate [18F] fluorinated species.

Polylactic acid composition

A resin composition which comprises polylactic acid, does not release an isocyanate group at the time of production and has excellent hydrolysis resistance and a low environmental burden. The resin composition comprises: (A) 100 parts by weight of a resin component (component A) containing polylactic acid (component A-α);(B) 0.001 to 10 parts by weight of a compound (component B) having one carbodiimide group and a cyclic structure in which first nitrogen and second nitrogen are bonded to each other via a bonding group, the cyclic structure consisting of 8 to 50 atoms; and(C) 0.001 to 2 parts by weight of at least one antioxidant (component C) selected from the group consisting of a hindered phenol-based compound, a phosphite-based compound, a phosphonite-based compound and a thioether-based compound.

Real-Time Reaction Monitoring of an Organic Multistep Reaction by Electrospray Ionization-Ion Mobility Spectrometry

The capability of electrospray ionization (ESI)-ion mobility (IM) spectrometry for reaction monitoring is assessed both as a stand-alone real-time technique and in combination with HPLC. A three-step chemical reaction, consisting of a Williamson ether synthesis followed by a hydrogenation and an N-alkylation step, is chosen for demonstration. Intermediates and products are determined with a drift time to mass-per-charge correlation. Addition of an HPLC column to the setup increases the separation power and allows the determination of further species. Monitoring of the intensities of the various species over the reaction time allows the detection of the end of reaction, determination of the rate-limiting step, observation of the system response in discontinuous processes, and optimization of the mass ratios of the starting materials. However, charge competition in ESI influences the quantitative detection of substances in the reaction mixture. Therefore, two different methods are investigated, which allow the quantification and investigation of reaction kinetics. The first method is based on the pre-separation of the compounds on an HPLC column and their subsequent individual detection in the ESI-IM spectrometer. The second method involves an extended calibration procedure, which considers charge competition effects and facilitates nearly real-time quantification.