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102266-59-1

3-Pyridinecarbonitrile, 4-amino-2-ethoxy-1,6-dihydro-6-oxois a chemical compound with the molecular formula C8H9N3O2. It is a derivative of 3-pyridinecarbonitrile, featuring an amino group at the 4th position, an ethoxy group at the 2nd position, and a dihydro-6-oxo substituent. 3-Pyridinecarbonitrile, 4-amino-2-ethoxy-1,6-dihydro-6-oxomay have potential applications in pharmaceutical research and drug development due to its unique structural features. Careful handling and adherence to safety protocols are essential when working with this chemical to avoid potential hazards.

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  • 102266-59-1 Structure

  • Basic information

    1. Product Name: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-
    2. Synonyms: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-;4-amino-2-ethoxy-6-hydroxynicotinonitrile
    3. CAS NO:102266-59-1
    4. Molecular Formula: C8H9N3O2
    5. Molecular Weight: 179.18
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 102266-59-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-(102266-59-1)
    11. EPA Substance Registry System: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-(102266-59-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 102266-59-1(Hazardous Substances Data)

102266-59-1 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
3-Pyridinecarbonitrile, 4-amino-2-ethoxy-1,6-dihydro-6-oxois used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structural features, including the presence of an amino group, ethoxy group, and dihydro-6-oxo substituent, make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-Pyridinecarbonitrile, 4-amino-2-ethoxy-1,6-dihydro-6-oxois utilized as a building block for the design and synthesis of novel bioactive molecules. Its versatile functional groups allow for further chemical modifications and optimization, leading to the discovery of potential drug candidates with improved pharmacological properties.
Used in Chemical Synthesis:
3-Pyridinecarbonitrile, 4-amino-2-ethoxy-1,6-dihydro-6-oxoserves as a key intermediate in the synthesis of various organic compounds and specialty chemicals. Its unique structural features enable it to participate in a wide range of chemical reactions, facilitating the production of diverse chemical entities for various applications across different industries.

Check Digit Verification of cas no

The CAS Registry Mumber 102266-59-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,2,6 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 102266-59:
(8*1)+(7*0)+(6*2)+(5*2)+(4*6)+(3*6)+(2*5)+(1*9)=91
91 % 10 = 1
So 102266-59-1 is a valid CAS Registry Number.

102266-59-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-amino-2-ethoxy-6-oxo-1H-pyridine-3-carbonitrile

1.2 Other means of identification

Product number -
Other names 4-Amino-2-Ethoxy-6-Hydroxy-Pyridine-3-Carbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:102266-59-1 SDS

102266-59-1Relevant articles and documents

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors

Zhao, Hongyu,Serby, Michael D.,Xin, Zhili,Szczepankiewicz, Bruce G.,Liu, Mei,Kosogof, Christi,Liu, Bo,Nelson, Lissa T. J.,Johnson, Eric F.,Wang, Sanyi,Pederson, Terry,Gum, Rebecca J.,Clampit, Jill E.,Haasch, Deanna L.,Abad-Zapatero, Cele,Fry, Elizabeth H.,Rondinone, Cristina,Trevillyan, James M.,Sham, Hing L.,Liu, Gang

, p. 4455 - 4458 (2006)

C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK inhibitors could be valuable tools to study the therapeutic benefits of inhibiting these enzymes and as leads for potential drugs targeting JNKs. In this report, we disclose a series of potent and highly selective JNK inhibitors with good pharmacokinetic profiles.

Inhibitors of c-Jun N-terminal kinases

-

Page/Page column 35; 53, (2008/06/13)

The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

Syntheses with Nitriles, LXXIV. - 3-Amino-4,4-dicyano-3-butenoate, a Synthetically Useful Dimer from Malononitrile and Cyanoacetate

Mittelbach, Martin,Junek, Hans

, p. 533 - 544 (2007/10/02)

An improved synthesis of 3-amino-4,4-dicyano-3-butenoate (4) (a codimer from cyanoacetate and malononitrile) is described.The 13C NMR data and pKa value of 4 are compared with those of the isomeric codimer 3 and the dimers 1 and 2.Reaction of 4 with acids or bases leads to the 2(1H)-pyridones 8 and 9, respectively.Conversions of 4 with aldehydes, ketones, and nitroso compounds give the products 11,14, and 15 as well as the benzopyran derivatives 12 and the 2-oxochinoline derivative 13 when using 2-hydroxy- and 2-aminobenzaldehydes. 4 reacts with formamidine to yield the dihydropyrimidine derivative 17 and with sulfur to give the 3,5-diamino-4-cyano-2-thiophenecarboxylates (18).

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