102336-06-1

Basic information

• Product Name: 2-phenylmethyloxy-4-methylpyridine
• Synonyms: 2-phenylmethyloxy-4-methylpyridine
• CAS NO: 102336-06-1
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199
• Mol File: 102336-06-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-phenylmethyloxy-4-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylmethyloxy-4-methylpyridine(102336-06-1)
• EPA Substance Registry System: 2-phenylmethyloxy-4-methylpyridine(102336-06-1)

Safety Data

• Hazardous Substances Data: 102336-06-1(Hazardous Substances Data)

Upstream product

• 3678-62-4 2-chloro-4-picoline 
• 100-51-6 benzyl alcohol 
• 4926-28-7 2-Bromo-4-picoline 
• 695-34-1 2-Amino-4-methylpyridine 
• 13466-41-6 2-hydroksy-4-methyl-pyridine 
• 100-39-0 benzyl bromide 

Downstream Products

• 102336-05-0 3-(2-benzyloxy-4-pyridyl)propionic acid 
• 119836-20-3 methyl 3-(2-benzyloxy-4-pyridyl)propionate 

Relevant articles and documents

SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINES AND IMIDAZO[1,2-A]PYRAZINES AND THEIR USE

The present application relates to novel substituted pyrazolo[1,5-a]pyridines and imidazo[1,2-a]pyrazines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF

The present application relates to novel pyrazolo[1,5-a] pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

MEDICINAL COMPOSITIONS

The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.

Substituted 1,3-thiazole compounds, their production and use

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

An optionally N-oxidized compound represented by the formula: wherein R1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R2 represents an aromatic group, R3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR4 (R4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.

Synthesis of 2-Substituted 4-Pyridylpropionates. Part 2. Alkylation Approach

A synthesis of methyl 3-(2-methoxy-4-pyridyl)propionate (2), a key intermediate in the synthesis of the potent long-acting histamine H2-receptor antagonist SK&F 93574 (1), is described.The key step in the synthesis of compound (1) involves alkylation of 2-methoxy-4-methylpyridine (5) with sodium chloroacetate in the presence of sodamide.The scope and limitations of the alkylation is investigated using a variety of electrophiles.The application of this reaction to other 2-substituted 4-methylpyridines is also discussed.