10252-63-8

Basic information

• Product Name: 4-(methylsulfamoyl)benzoate
• Synonyms: 4-(methylsulfamoyl)benzoate;benzoic acid, 4-[(methylamino)sulfonyl]-;4-(N-MethylsulfaMoyl)benzoic acid;4-(N-Methylsulfamoyl)
• CAS NO: 10252-63-8
• Molecular Formula: C₈H₉NO₄S
• Molecular Weight: 215.23
• Mol File: 10252-63-8.mol

Chemical Properties

• Boiling Point: 405.9°Cat760mmHg
• Flash Point: 199.3°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 2.58E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(methylsulfamoyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methylsulfamoyl)benzoate(10252-63-8)
• EPA Substance Registry System: 4-(methylsulfamoyl)benzoate(10252-63-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 10252-63-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(methylsulfamoyl)benzoate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its chemical structure allows for the creation of compounds with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(methylsulfamoyl)benzoate is utilized as an intermediate in the production of agrochemicals, leveraging its chemical properties to enhance crop protection and yield.
Used in Dye and Pigment Synthesis:
4-(methylsulfamoyl)benzoate is used as a key component in the synthesis of dyes and pigments, where its chemical structure contributes to the color and stability of these products.
Used in Antimicrobial and Anti-Fungal Applications:
Due to its antimicrobial and antifungal properties, 4-(methylsulfamoyl)benzoate is used in various industrial and agricultural applications to prevent the growth of harmful microorganisms, thereby preserving materials and ensuring product safety.
These applications highlight the versatility and importance of 4-(methylsulfamoyl)benzoate in different industries, showcasing its potential for further development and use in innovative products and processes.

InChI:InChI=1/C8H9NO4S/c1-9-14(12,13)7-4-2-6(3-5-7)8(10)11/h2-5,9H,1H3,(H,10,11)/p-1

Upstream product

• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 593-51-1 methylamine hydrochloride 
• 86674-13-7 4-(methyl-nitro-sulfamoyl)-benzoic acid 
• 74-89-5 methylamine 
• 56236-82-9 4-cyano-N-methylbenzenesulfonamide 

Downstream Products

• 1421506-10-6 (E)-4-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulfonamide 
• 13092-93-8 4-formyl-N-methyl-benzenesulfonamide 
• 1251152-57-4 C₂₄H₂₂N₄O₄S 
• 1204331-59-8 C₃₀H₃₀F₃N₅O₆S 
• 325458-24-0 N-(6-chloropyridin-3-yl)-4-methylsulfamoyl-benzamide 
• 1204331-59-8 4-[4-(4-(N'-carbobenzyloxy)-guanidinocarbonyl-2-trifluoromethyl-phenyl)-piperidine-1-carbonyl]-N-methyl-benzenesulfonamide 
• 660432-44-0 4-hydroxymethyl-N-methyl-benzenesulfonamide 
• 71888-27-2 N-methyl-1,3-dihydro-1-oxo-3,3-diphenyl-5-isobenzofuransulfonamide 
• 71888-23-8 N,N-diethyl-4<(methylamino)sulfonyl>benzamide 
• 86674-13-7 4-(methyl-nitro-sulfamoyl)-benzoic acid 
• 858810-67-0 4-methylsulfamoyl-benzoyl chloride 

Relevant articles and documents

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

The benzylideneindolinone 6-chloro-3-(3′-trifluoromethylbenzylidene)-1,3-dihydroindol-2-one (4) was reported to exhibit potent and selective growth inhibitory effects on hepatocellular carcinoma (HCC). Corroborative evidence supported multi-receptor tyrosine kinase (RTK) inhibition as a possible mode of action. However, the poor physicochemical properties of 4 limited its furtherance as a lead compound. In this study, the modification of 4 was investigated with the aim of improving its potency and physicochemical profile. The 6-fluorobenzylideneindolinone 3-12 bearing a 3′-N-propylaminosulfonyl substituent was found to be a promising substitute. Compound 3-12 [6-fluoro-3-(3′-N-propylaminosulfonylbenzylidene)-1,3-dihydroindol-2-one] was found to be tenfold more soluble than 4 and to have sub-micromolar growth inhibitory activities on HCC cells. It is apoptogenic and inhibits the phosphorylation of several RTKs in HuH7, of which the inhibition of FGFR4 and HER3 are prominent. Compound 3-12 decreased the tumor load in a physiologically relevant orthotopic HCC xenograft murine model. Structure-activity relationships support pivotal roles for the fluoro and N′-propylaminosulfonyl moieties in enhancing cell-based activity and moderating the physicochemical profile (solubility, permeability) of 3-12.

BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE

Compounds of general formula I: wherein R1a, R1b, R2, R3a, R3b and X are as defined herein are tyrosine kinase inhibitors and are useful for the treatment of various diseases and conditions, for examp

Hydrogenated Benzo (C) Thiophene Derivatives as Immunomodulators

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

HYDROGENATED BENZO (C) THIOPHENE DERIVATIVES AS IMMUNOMODULATORS

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

EFFECT OF STRUCTURE ON THE KINETICS AND MECHANISM OF THE ACID-CATALYZED DECOMPOSITION OF N-ALKYL-N-NITROBENZENESULFONAMIDES

The decomposition rate of a series of meta- and para-substituted N-alkyl-N-nitrobenzenesufonamides was determined by a spectrophotometric method in aqueous sulfuric acid.It was shown that the decomposition of the compounds takes place both by denitration and by cleavage of the N-S bond with the formation fo primary aliphatic N-nitrosamines.Electron-withdrawing substituents in the aromatic ring shift the process toward denitration.