13092-93-8

Usage

Uses

Used in Organic Synthesis:
4-formyl-N-methylbenzenesulfonamide(SALTDATA: FREE) is utilized as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-formyl-N-methylbenzenesulfonamide(SALTDATA: FREE) serves as a valuable compound for the development of new drugs, given its potential to be modified and incorporated into medicinal molecules.
Used in Antimicrobial Applications:
Leveraging its antimicrobial properties, 4-formyl-N-methylbenzenesulfonamide(SALTDATA: FREE) is studied for its potential use as an antibiotic, offering a possible alternative for treating bacterial infections.
Used in Cancer Treatment Research:
4-formyl-N-methylbenzenesulfonamide(SALTDATA: FREE) is being investigated for its role in the treatment of cancer, with the aim of developing new therapeutic agents that could target and combat cancer cells.
Used in Infectious Disease Treatment Research:
4-formyl-N-methylbenzenesulfonamide(SALTDATA: FREE) is also explored for its potential in treating various infectious diseases, suggesting that it may have broad-spectrum activity against different pathogens.
Overall, 4-formyl-N-methylbenzenesulfonamide(SALTDATA: FREE) is a versatile chemical with a wide range of potential applications in medicine and chemistry, making it a subject of interest for researchers and practitioners in these fields.

Upstream product

• 3240-35-5 4-formyl-benzenesulfonamide 
• 77-78-1 dimethyl sulfate 
• 64-18-6 formic acid 
• 98-61-3 p-Iodobenzenesulfonyl chloride 
• 593-51-1 methylamine hydrochloride 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 10252-63-8 4-methylsulfamoyl-benzoic acid 
• 660432-44-0 4-hydroxymethyl-N-methyl-benzenesulfonamide 

Downstream Products

• 1569975-54-7 4-(1-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)-N-methylbenzenesulfonamide 
• 1421506-10-6 (E)-4-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulfonamide 
• 1415591-24-0 C₂₂H₁₉ClN₂O₃S 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

The benzylideneindolinone 6-chloro-3-(3′-trifluoromethylbenzylidene)-1,3-dihydroindol-2-one (4) was reported to exhibit potent and selective growth inhibitory effects on hepatocellular carcinoma (HCC). Corroborative evidence supported multi-receptor tyrosine kinase (RTK) inhibition as a possible mode of action. However, the poor physicochemical properties of 4 limited its furtherance as a lead compound. In this study, the modification of 4 was investigated with the aim of improving its potency and physicochemical profile. The 6-fluorobenzylideneindolinone 3-12 bearing a 3′-N-propylaminosulfonyl substituent was found to be a promising substitute. Compound 3-12 [6-fluoro-3-(3′-N-propylaminosulfonylbenzylidene)-1,3-dihydroindol-2-one] was found to be tenfold more soluble than 4 and to have sub-micromolar growth inhibitory activities on HCC cells. It is apoptogenic and inhibits the phosphorylation of several RTKs in HuH7, of which the inhibition of FGFR4 and HER3 are prominent. Compound 3-12 decreased the tumor load in a physiologically relevant orthotopic HCC xenograft murine model. Structure-activity relationships support pivotal roles for the fluoro and N′-propylaminosulfonyl moieties in enhancing cell-based activity and moderating the physicochemical profile (solubility, permeability) of 3-12.

BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE

Compounds of general formula I: wherein R1a, R1b, R2, R3a, R3b and X are as defined herein are tyrosine kinase inhibitors and are useful for the treatment of various diseases and conditions, for examp

Hydrogenated Benzo (C) Thiophene Derivatives as Immunomodulators

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

HYDROGENATED BENZO (C) THIOPHENE DERIVATIVES AS IMMUNOMODULATORS

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.