10268-79-8Relevant articles and documents
Azobenzene-diamides as Photopharmacological Ligands for Insect Ryanodine Receptor
Chen, Meijun,Li, Yuxin,Shao, Xusheng,Wang, Long,Xia, Shanshan,Xu, Zhiping
, p. 14409 - 14416 (2020)
Photoresponsive ligands are powerful tool compounds for studying receptor function with spatiotemporal resolution. However, to the best of our knowledge, such a ligand is not available for the ryanodine receptor (RyR). Herein, we present a photochromic ligand (PCL) for insect RyR by decorating chlorantraniliprole (CHL) with photoswitchable azobenzene (AB). We demonstrated that one potent ligand, named ABCHL13, shows light-induced reversible trans-cis isomerization and 3.5-fold insecticidal activity decrease toward oriental armyworm (Mythimna separata) after UV-light irradiation, that is, trans-ABCH13 has higher activity than the cis-ABCH13. ABCHL13 enables optical control over intracellular Ca2+ release in dorsal unpaired median (DUM) neurons of M. separata and American cockroach (Periplaneta americana) and cardiac function of P. americana. Our results provide a first photopharmacological toolkit that is applicable to light-dependent regulation of RyR and heart beating.
A Sandwich Azobenzene–Diamide Dimer for Photoregulated Chloride Transport
Ahmad, Manzoor,Metya, Surajit,Das, Aloke,Talukdar, Pinaki
, p. 8703 - 8708 (2020)
There has been a tremendous evolution for artificial ion transport systems, especially gated synthetic systems, which closely mimic their natural congeners. Herein, we demonstrate a trans-azobenzene-based photoregulatory anionophoric system that transports chloride by forming a sandwich dimeric complex. Further studies confirmed a carrier-mediated chloride-anion antiport mechanism, and the supramolecular interactions involved in chloride recognition within the sandwich complex were revealed from theoretical studies. Reversible trans–cis photoisomerization of the azobenzene was achieved without any significant contribution from the thermal cis→trans isomerization at room temperature. Photoregulatory transport activity across the lipid bilayer membrane inferred an outstanding off-on response of the azobenzene photoswitch.
Zeolites. Efficient and eco-friendly catalysts for the synthesis of benzimidazoles
Heravi, Majid M.,Tajbakhsh, Mahmood,Ahmadi, Amir N.,Mohajerani, Bagher
, p. 175 - 179 (2007/10/03)
A superior method of synthesis of 2-substituted benzimidazoles by means of the heterogeneous catalysis of synthetic and natural zeolites in the reaction of 1,2-diaminobenzene with acid chlorides is described. Springer-Verlag 2005.
