102735-90-0Relevant articles and documents
ANTICANCER AGENT
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, (2013/03/26)
An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.
Direct Acting, Highly Mutagenic, α-Hydroxy N-Nitrosamines from 4-Chloroindoles
Buechi, George,Lee, Gary C. M.,Yang, David,Tannenbaum, Steven R.
, p. 4115 - 4119 (2007/10/02)
Fave beans (Vicia fava) contain 4-chloro-6-methoxyindole, a promutagen, which on nitrosation under simulated gastric conditions forms 4-chloro-6-methoxy-2-hydroxy-N1-nitrosoindolin-3-one oxime, a direct-acting, exceedingdly potent, mutagen whic