10315-89-6

Basic information

• Product Name: 1-(2-methylpropyl)piperidine
• Synonyms: Piperidine, 1-(2-methylpropyl)-
• CAS NO: 10315-89-6
• Molecular Formula: C₉H₁₉N
• Molecular Weight: 141.2539
• Mol File: 10315-89-6.mol

Chemical Properties

• Melting Point: 144-145 °C
• Boiling Point: 160.5°C at 760 mmHg
• Flash Point: 53.4°C
• Density: 0.838g/cm³
• Vapor Pressure: 2.38mmHg at 25°C
• Refractive Index: 1.448
• PKA: 9.93±0.10(Predicted)
• CAS DataBase Reference: 1-(2-methylpropyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methylpropyl)piperidine(10315-89-6)
• EPA Substance Registry System: 1-(2-methylpropyl)piperidine(10315-89-6)

Safety Data

• Hazardous Substances Data: 10315-89-6(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 78-77-3 Isobutyl bromide 
• 513-38-2 Isobutyl iodide 
• 92145-59-0 1-(2-methylprop-2-enyl)piperidine 
• 857832-72-5 1-(3-hydroxy-2,2-dimethyl-butyryl)-piperidine 
• 123-91-1 1,4-dioxane 
• 75-30-9 2-iodo-propane 
• 50-00-0 formaldehyd 
• 673-33-6 1-piperidino-1-isobutene 
• 17201-04-6 2-methyl-1-(piperidin-1-yl)propan-1-one 
• 78-83-1 2-methyl-propan-1-ol 

Relevant articles and documents

Amination of aliphatic alcohols catalyzed by CuO-NiO/γ-Al 2O3

The amination of aliphatic alcohols in the gas-solid phase was investigated in a fixed-bed reactor in the presence of CuO-NiO/γ-Al2O 3 as the catalyst. This catalytic system was successfully applied for both the N-methylation of aliphatic amines and N-alkylation of piperidine with primary or secondary alcohols. N-Alkylation of piperidine with low-carbon alcohols resulted in high conversions and selectivities, and the conversion of piperidine and the selectivities toward the desired products declined gradually with the increase of the carbon number of aliphatic alcohols. The influence of varied conditions on the N-cyclohexylation of piperidine was also evaluated, including liquid hourly space velocity (LHSV), temperature and the catalyst; especially the catalyst had the greatest impact. Finally, the test of the catalyst's stability was performed.

A novel aminomethylation reaction of gaseous alkanes with tert-methylamine N-oxides via C-H bond activation by copper(II) salts

The Cu(OAc)2/CF3COOH (TFA) system catalyzes the aminomethylation of gaseous alkanes such as propane and ethane with trimethylamine N-oxide to give N,N-dimethylisobutylamine (1) and N,N-dimethylpropylamine (7), respectively.The corresponding trifluoroacetates are also formed as by-products from the reactions of methane and propane. Keywords: Copper acetate; Aminomethylation; Amine N-oxide; C-H bond activation; C-C bond formation; Alkane

Aminomethylation of organic halides promoted by zinc in protic medium

Organic halides undergo smooth aminomethylation by secondary amines and aqueous formaldehyde promoted by metallic zinc under copper(I) catalysis. Good to excellent yields are obtained with primary, secondary, and tertiary iodides, allylic, propargylic, and benzylic bromides and with α-bromoesters. In most cases, DMSO is the best solvent, but dioxane is preferable for some more reactive halides. Additional experiments with radical quenchers and promoters and the use of 'radical clocks' indicate a stepwise reaction mechanism initiated by the attack of an alkyl radical to iminium ion.

Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides

The development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the d

Colloid and nanosized catalysts in organic synthesis: IX hydrogenation of enamines with hydrogen at atmospheric pressure

Hydrogenation of enamines with hydrogen at atmospheric pressure was performed using nickel nanoparticles as a catalyst. The reaction may be used to produce tertiary amines under mild conditions using an accessible catalyst.

Catalytic hydrogenation of amides to amines under mild conditions

Under (not so much) pressure: A general method for the hydrogenation of tertiary and secondary amides to amines with excellent selectivity using a bimetallic Pd-Re catalyst has been developed. The reaction proceeds under low pressure and comparatively low temperature. This method provides organic chemists with a simple and reliable tool for the synthesis of amines. Copyright

An efficient metal-free reduction using diphenylsilane with (tris-perfluorophenyl)borane as catalyst

An efficient metal-free reduction of various C{double bond, long}X (X = O, N, C) bonds into their corresponding amines or hydrocarbons using the Ph2SiH2/B(C6F5)3 catalytic system is demonstrated. This protocol reduces enamines, enol esters, carbonyls, amides, and isocyanates.

Preparation of amines by the reduction of imines with phosphorous acid

This invention relates to the preparation of amines by the reduction of imines with phosphorous acid, preferably under basic conditions.