Piperidine, 1-(2-methylpropyl)-

Base Information

• Chemical Name: Piperidine, 1-(2-methylpropyl)-
• CAS No.: 10315-89-6
• Molecular Formula: C9H19 N
• Molecular Weight: 141.257
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70145674
• Nikkaji Number: J1.172.243A
• Wikidata: Q83010242
• Mol file: 10315-89-6.mol

Synonyms:1-(2-Methylpropyl)-piperidine;10315-89-6;Piperidine, 1-(2-methylpropyl)-;1-Isobutyl-piperidine;1-(2-methylpropyl)piperidine;SCHEMBL426509;DTXSID70145674;BNBLWPUWMNURAX-UHFFFAOYSA-N

Chemical Property of Piperidine, 1-(2-methylpropyl)-

Chemical Property:

• Vapor Pressure: 2.38mmHg at 25°C
• Melting Point: 144-145 °C
• Boiling Point: 160.5°Cat760mmHg
• PKA: 9.93±0.10(Predicted)
• Flash Point: 53.4°C
• PSA: 3.24000
• Density: 0.838g/cm³
• LogP: 2.06620
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 141.151749610
• Heavy Atom Count: 10
• Complexity: 82.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CN1CCCCC1

Technology Process of Piperidine, 1-(2-methylpropyl)-

There total 11 articles about Piperidine, 1-(2-methylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-piperidino-1-isobutene (673-33-6) → N-isobutylpiperidine (10315-89-6)

Guidance literature:

With sodium tetrahydroborate; hydrogen; nickel dichloride; In isopropyl alcohol; at 50 ℃; for 5h; under 760.051 Torr;

DOI:10.1134/S1070363214110036

Reference yield: 84.0%

piperidine (110-89-4) + 2-iodo-propane (75-30-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → N-isobutylpiperidine (10315-89-6)

Guidance literature:

With acetic acid; zinc; copper(l) iodide; In water; dimethyl sulfoxide; at 30 ℃; for 2h;

DOI:10.1016/j.tetlet.2005.08.139

Reference yield: 76.0%

2-methyl-1-(piperidin-1-yl)propan-1-one (17201-04-6) → N-isobutylpiperidine (10315-89-6)

Guidance literature:

2-methyl-1-(piperidin-1-yl)propan-1-one; With oxalyl dichloride; hydrogen; tris(2,6-difluorophenyl)borane triethylphosphine oxide; In chloroform; at 70 ℃; for 22h; under 60006 Torr; Glovebox; Sealed tube;

With sodium carbonate; In water;

DOI:10.1055/a-1681-3972

upstream raw materials:

piperidine

Isobutyl bromide

Isobutyl iodide

1-(2-methylprop-2-enyl)piperidine

Refernces

• 1、 Huang, Jia-Min,Qian, Chao,Feng, Lie,Chen, Yun-Bin,Chen, Xin-Zhi. "Amination of aliphatic alcohols catalyzed by CuO-NiO/γ-Al 2O3". . p. 1187 - 1190. Retrieved 2013.
• 2、 Hjortdahl. "-". . . Retrieved 1882.
• 3、 Drake,McElvain. "-". . p. 1155,1156. Retrieved 1933.
• 4、 Estevam, Idália H. S.,Da Silva, Margarete F.,Bieber, Lothar W.. "Aminomethylation of organic halides promoted by zinc in protic medium". . p. 7601 - 7604. Retrieved 2005.
• 5、 Mokhov,Popov,Nebykov. "Colloid and nanosized catalysts in organic synthesis: IX hydrogenation of enamines with hydrogen at atmospheric pressure". . p. 2073 - 2075. Retrieved 2015/02/02.