10333-64-9

Basic information

• Product Name: (1-Methyl-piperidin-4-yl)-acetaldehyde
• Synonyms: (1-Methyl-piperidin-4-yl)-acetaldehyde;N-METHYL-4-PIPERDINE ACETALDEHYDE;1-Methyl-4-piperidine acetaldehyde;N-Methyl-4-piperidine acetaldehyde;1-Methyl-4-(2-oxoethyl)piperidine
• CAS NO: 10333-64-9
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.2108
• Product Categories: Aldehydes;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 10333-64-9.mol

Chemical Properties

• Boiling Point: 202.179 °C at 760 mmHg
• Flash Point: 64.192 °C
• Appearance: /
• Density: 0.927 g/cm³
• Vapor Pressure: 0.296mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.19±0.10(Predicted)
• CAS DataBase Reference: (1-Methyl-piperidin-4-yl)-acetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Methyl-piperidin-4-yl)-acetaldehyde(10333-64-9)
• EPA Substance Registry System: (1-Methyl-piperidin-4-yl)-acetaldehyde(10333-64-9)

Safety Data

• Hazardous Substances Data: 10333-64-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1-Methyl-piperidin-4-yl)-acetaldehyde is used as a key intermediate in the synthesis of potent and selective agonists for the 5-HT1D receptor. These agonists are employed as antipsychotic agents, helping to manage the symptoms of various mental disorders by modulating the activity of the serotonin system in the brain.
Additionally, (1-Methyl-piperidin-4-yl)-acetaldehyde can be utilized in the development of other therapeutic agents targeting different receptors or enzymes, depending on the specific chemical modifications made to its structure. Its reactivity and structural features make it a valuable building block in medicinal chemistry for creating novel and effective drugs.

InChI:InChI=1/C8H15NO/c1-9-5-2-8(3-6-9)4-7-10/h7-8H,2-6H2,1H3

Upstream product

• 95533-25-8 N-Methyl-4-(carbomethoxymethylidenyl)piperidine 
• 1445-73-4 1-Methyl-4-piperidone 
• 154594-25-9 (1-Methyl-piperidin-4-ylidene)-acetic acid methyl ester 
• 10333-62-7 4-(2,2-dimethoxyethyl)-1-methylpiperidine 
• 50675-21-3 N-methyl-piperidine-4-carboxaldehyde 

Downstream Products

• 121679-13-8 naratriptan 

Relevant articles and documents

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

4-substituted 1,2,4-triazole derivatives

A discrete class of 4-substituted 1,2,4-triazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogues: Potent and selective agonists for 5-HT(1D) receptors

Optimisation of a series of 5-(heterocyclyl)tryptamines led to the identification of the symmetrically substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT(1D) receptor affinity and selectivity. The triazole (8) is the most potent and selective, orally bioavailable, 5-HT(1D) receptor agonist identified to date, showing an order of magnitude greater potency than the clinical compound sumatriptan with improved subtype selectivity.

4-Substituted 1,2,4-triazole derivatives

4-substituted 1,2,4-triazole derivatives of formula I: wherein R represents a 2-(dimethylamino)ethyl group, or a group of formula (i) or (ii): or a salt or prodrug thereof;, are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

Indole derivatives

Compounds are disclosed of formula (I) STR1 wherein R1 represents a C1-6 alkyl group; R2 represents a hydrogen atom or a C1-3 alkyl group; n represents zero or an integer from 1 to 3; and pharmaceutically accept