- Synthesis of novel 6-(2-aminopyrimidin-4-yl) benzoxazinones
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N-Methylation of 2H-benzo [1,4] oxazin-3-one (1) with dimethyl sulphate in toluene containing KOH at 35-40° for 15 min. gave 4-methyl-4H-benzo [1,4] oxazin-3-one (2). Nitration of 2 with the usual nitrating mixture gave 4-methyl-6-nitro-4H-benzo [1,4] oxa
- Rajitha, Ch.,Vineel, B. George,Venkataiah,Dubey
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p. 325 - 328
(2019/01/21)
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- Synthesis of novel fused 2-aminobenzothiazole derivatives
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2-Amino-4-nitrophenol (3) was treated with chloroacetyl chloride in the presence of NaHCO3 and triethylbenzylammonium chloride in acetonitrile to afford 6-nitro-4Hbenzo [1,4] oxazin-3-one (4). The latter, on treatment with Mel gave 4-methyl-6-n
- Rajitha, Ch.,George Vineel,Venkataiah,Dubey
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p. 111 - 114
(2019/01/21)
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- DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
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Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds a
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Page/Page column 30
(2010/07/04)
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- 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor
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This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.
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Page/Page column 69
(2010/11/08)
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- 6- OR 7-(2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS
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Compounds having α adrenergic activity and useful for the treatment of glaucoma, renal and gastrointestinal disorders and vasoconstictors have the formula STR1 where R 1 is independently H, or lower alkyl or 1 to 6 carbons; R 2 is independently H, or lower alkyl of 1 to 6 carbons or the two R 2 symbols jointly represent a carbonyl oxygen; R 3 is H, lower alkyl of one to 6 carbons, O, OH and OR 7 where R 7 is lower alkyl of 1 to 6 carbons, or R 3 is COH or COR 8 where R 8 is lower alkyl of 1 to 6 carbons; R 4 and R 5 independently is H, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl with the proviso that when the R 2 groups symbolize a carbonyl oxygen then R 4 and R 5 both cannot be hydrogen; R 6 is hydrogen, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl, and the R 5 and the (2-imidazoline-2-yl)amino substituents are connected mutually exclusively to the 6 and 7 positions of the 1,4-benzoxazine nucleus.
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- Synthesis and Anthelmintic Activity of Some New 6- and 7-Isothiocyanato-2H-1,4-benzoxa(thia)zin-3(4H)-ones and Benzoxa(thia)zin-3(4H)-thiones
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A series of 6- and 7-isothiocyanato-2H-1,4-benzoxa(thia)zin-3(4H)-ones (8a-n, 9a-c, 12a-i and 12l) and thiones (10a-h and 11a-c) has been prepared for anthelmintic testing.Some of these compounds possess a significant degree of activity against hookworm i
- Shridhar, D. R.,Rao, K. Srinivasa,Singh, A. N.,Rastogi, K.,Jain, M. L.,et al.
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p. 1263 - 1267
(2007/10/02)
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