- Synthesis of novel 6-(2-aminopyrimidin-4-yl) benzoxazinones
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N-Methylation of 2H-benzo [1,4] oxazin-3-one (1) with dimethyl sulphate in toluene containing KOH at 35-40° for 15 min. gave 4-methyl-4H-benzo [1,4] oxazin-3-one (2). Nitration of 2 with the usual nitrating mixture gave 4-methyl-6-nitro-4H-benzo [1,4] oxa
- Rajitha, Ch.,Vineel, B. George,Venkataiah,Dubey
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p. 325 - 328
(2019/01/21)
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- Synthesis of novel fused 2-aminobenzothiazole derivatives
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2-Amino-4-nitrophenol (3) was treated with chloroacetyl chloride in the presence of NaHCO3 and triethylbenzylammonium chloride in acetonitrile to afford 6-nitro-4Hbenzo [1,4] oxazin-3-one (4). The latter, on treatment with Mel gave 4-methyl-6-n
- Rajitha, Ch.,George Vineel,Venkataiah,Dubey
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p. 111 - 114
(2019/01/21)
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- DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
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Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds a
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Page/Page column 30
(2010/07/04)
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- 6- OR 7-(2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS
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Compounds having α adrenergic activity and useful for the treatment of glaucoma, renal and gastrointestinal disorders and vasoconstictors have the formula STR1 where R 1 is independently H, or lower alkyl or 1 to 6 carbons; R 2 is independently H, or lower alkyl of 1 to 6 carbons or the two R 2 symbols jointly represent a carbonyl oxygen; R 3 is H, lower alkyl of one to 6 carbons, O, OH and OR 7 where R 7 is lower alkyl of 1 to 6 carbons, or R 3 is COH or COR 8 where R 8 is lower alkyl of 1 to 6 carbons; R 4 and R 5 independently is H, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl with the proviso that when the R 2 groups symbolize a carbonyl oxygen then R 4 and R 5 both cannot be hydrogen; R 6 is hydrogen, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl, and the R 5 and the (2-imidazoline-2-yl)amino substituents are connected mutually exclusively to the 6 and 7 positions of the 1,4-benzoxazine nucleus.
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- Synthesis and Anthelmintic Activity of Some New 6- and 7-Isothiocyanato-2H-1,4-benzoxa(thia)zin-3(4H)-ones and Benzoxa(thia)zin-3(4H)-thiones
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A series of 6- and 7-isothiocyanato-2H-1,4-benzoxa(thia)zin-3(4H)-ones (8a-n, 9a-c, 12a-i and 12l) and thiones (10a-h and 11a-c) has been prepared for anthelmintic testing.Some of these compounds possess a significant degree of activity against hookworm i
- Shridhar, D. R.,Rao, K. Srinivasa,Singh, A. N.,Rastogi, K.,Jain, M. L.,et al.
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p. 1263 - 1267
(2007/10/02)
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