21744-84-3

Basic information

• Product Name: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: BUTTPARK 148\07-41;4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE;4-METHYLBENZO[B]MORPHOLIN-3-ONE;4-(N-METHYL)-1,4-BENZOXAZINE-3-ONE;4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE, 98 %;4-Methyl-2H-1,4-Benzoxazin-3-one;4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS NO: 21744-84-3
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Product Categories: Miscellaneous;API intermediates;Benzoxazines;Building Blocks;Heterocyclic Building Blocks
• Mol File: 21744-84-3.mol

Chemical Properties

• Melting Point: 57-60 °C(lit.)
• Boiling Point: 369.51 °C at 760 mmHg
• Flash Point: 177.274 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 1.18E-05mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.49±0.20(Predicted)
• CAS DataBase Reference: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(21744-84-3)
• EPA Substance Registry System: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(21744-84-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 21744-84-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Methyl-2H-1,4-benzoxazin-3(4H)-one is used as a heterocyclic building block for the synthesis of N-methyl benzomorpholine. 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE is significant in the development of novel pharmaceutical agents, potentially contributing to the creation of new drugs with diverse therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Methyl-2H-1,4-benzoxazin-3(4H)-one is utilized as a key intermediate for the preparation of various organic compounds. Its ability to undergo C-formylation under Friedel-Crafts reaction conditions highlights its versatility and potential in the synthesis of complex molecules for a wide range of applications, including materials science, agrochemicals, and specialty chemicals.

InChI:InChI=1/C9H9NO2/c1-10-7-4-2-3-5-8(7)12-6-9(10)11/h2-5H,6H2,1H3

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 74-88-4 methyl iodide 
• 112689-18-6 [2-(formyl-methyl-amino)-phenoxy]-acetic acid 
• 10541-78-3 2-methoxy-N-methylaniline 
• 79-04-9 chloroacetyl chloride 
• 21744-74-1 4-methyl-4H-benzo[1,4]oxazin-3-thione 
• 95-55-6 2-amino-phenol 
• 1878-87-1 2-nitrophenoxyacetic acid 
• 55860-22-5 2-chloro-N-(2-methoxyphenyl)acetamide 
• 468055-55-2 formic acid-(2-hydroxy-N-methyl-anilide) 
• 20308-28-5 N-methyl-o-ethoxyaniline 
• 824-39-5 sodium o-nitrophenate 
• 611-24-5 o-(N-methylamino)phenol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 104057-50-3 2-benzylidene-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 7699-21-0 4-methoxy-1-methyloxindole 
• 7699-23-2 7-methoxy-1-methylindolin-2-one 
• 77901-22-5 4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 27320-81-6 6-Chlorsulfonyl-4-methyl-2H-1,4-benzoxazin-3-on 
• 24036-47-3 6-bromo-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 114566-43-7 6-(2-chloracetyl)-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-on 
• 161530-37-6 (Z)-2-benzylidene-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 573-27-3 2-(N-acetyl-N-methylamino)phenol 
• 54695-97-5 2-(ethyl-methyl-amino)-phenol 
• 611-24-5 o-(N-methylamino)phenol 
• 404871-63-2 2-[(N-phenyl)thiocarboxyamido]-4-methyl-1,4-benzoxazin-(2H)-3-one 
• 851659-95-5 (Z)-4-methyl-2-(4-N,N-dimethylaminobenzylidenyl)-4H-benzo[1,4]oxazine-3-thione 
• 851659-96-6 (Z)-2-(4-isopropylbenzylidenyl)-4-methyl-4H-benzo[1,4]oxazine-3-thione 

Relevant articles and documents

Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia

Described herein are methods for using compounds that activate pyruvate kinase.

Synthesis of novel 6-(2-aminopyrimidin-4-yl) benzoxazinones

N-Methylation of 2H-benzo [1,4] oxazin-3-one (1) with dimethyl sulphate in toluene containing KOH at 35-40° for 15 min. gave 4-methyl-4H-benzo [1,4] oxazin-3-one (2). Nitration of 2 with the usual nitrating mixture gave 4-methyl-6-nitro-4H-benzo [1,4] oxa

BICYCLIC PKM2 ACTIVATORS

Compounds and compositions comprising compounds including formula (I) that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.

GLYCOSIDE DERIVATIVE AND USES THEREOF

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

GLYCOSIDE DERIVATIVE AND USES THEREOF

This invention relates to compounds represented by formula (I) wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

GLYCOSIDE DERIVATIVES AND USES THEREOF

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment

Glycoside Derivatives and Uses Thereof

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES

The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1 , R2 and n are as described in the description.

Synthesis of alkyl 4-alkyl-2-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylates as peptidomimetic building blocks

A general synthesis of new alkyl 4-alkyl-2-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate peptidomimetic building blocks from the corresponding alkyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylates through carbanion oxidation is described.