- Discovery of novel and potent CRTH2 antagonists
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High throughput screening of our chemical library for CRTH2 antagonists provided a lead compound 1a. Initial optimization of the lead led to the discovery of a novel, potent and orally bioavailable CRTH2 antagonist 17.
- Ito, Shinji,Terasaka, Tadashi,Zenkoh, Tatsuya,Matsuda, Hiroshi,Hayashida, Hisashi,Nagata, Hiroshi,Imamura, Yoshimasa,Kobayashi, Miki,Takeuchi, Makoto,Ohta, Mitsuaki
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- POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS
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The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.
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(2008/12/06)
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