1034020-21-7Relevant articles and documents
Discovery of novel and potent CRTH2 antagonists
Ito, Shinji,Terasaka, Tadashi,Zenkoh, Tatsuya,Matsuda, Hiroshi,Hayashida, Hisashi,Nagata, Hiroshi,Imamura, Yoshimasa,Kobayashi, Miki,Takeuchi, Makoto,Ohta, Mitsuaki
, p. 1194 - 1197 (2012)
High throughput screening of our chemical library for CRTH2 antagonists provided a lead compound 1a. Initial optimization of the lead led to the discovery of a novel, potent and orally bioavailable CRTH2 antagonist 17.