103418-56-0

Basic information

• Product Name: 5-(2-FURYL)-1,3,4-OXADIAZOL-2(3H)-ONE
• Synonyms: 5-(2-furanyl)-1,3,4-Oxadiazol-2(3H)-one
• CAS NO: 103418-56-0
• Molecular Formula: C₆H₄N₂O₃
• Molecular Weight: 152.11
• Mol File: 103418-56-0.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.65g/cm³
• Refractive Index: 1.684
• CAS DataBase Reference: 5-(2-FURYL)-1,3,4-OXADIAZOL-2(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-FURYL)-1,3,4-OXADIAZOL-2(3H)-ONE(103418-56-0)
• EPA Substance Registry System: 5-(2-FURYL)-1,3,4-OXADIAZOL-2(3H)-ONE(103418-56-0)

Safety Data

• Hazardous Substances Data: 103418-56-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H4N2O3/c9-6-8-7-5(11-6)4-2-1-3-10-4/h1-3H,(H,8,9)

Upstream product

• 75-44-5 phosgene 
• 3326-71-4 2-furoic acid hydrazide 
• 33621-21-5 (5-furan-2-yl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetic acid ethyl ester 
• 7732-18-5 water 
• 108-88-3 toluene 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 201230-82-2 carbon monoxide 
• 23571-76-8 2-(furan-2-yl)-1,3,4-oxadiazole 
• 13239-11-7 5-(furan-2-yl)-1,3,4-oxadiazole-2-thiol 

Downstream Products

• 103435-46-7 2-(2'-Furyl)-4-Tricyclohexylstannyl-5-Oxo-1,3,4-Oxadiazoline 
• 1024614-08-1 (1R,2R)-N,N'-bis(5-furan-2-yl-1,3,4-oxadiazol-2-yl)cyclohexane-1,2-diamine 

Relevant articles and documents

DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles

An unprecedented Cu-catalyzed direct annulation of hydrazides with N,N-dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4-oxadiazoles. This process features the short reaction time and can be safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4-oxadiazole-2(3H)-ones. Moreover, the mechanistic studies suggest that the source of CH is from the N-methyl group of DMF. (Figure presented.).

Palladium-catalyzed oxidative O-H/N-H carbonylation of hydrazides: Access to substituted 1,3,4-oxadiazole-2(3 H)-ones

A novel palladium-catalyzed oxidative annulation reaction for the C-O, C-N bond formations is developed. The intramolecular cyclocarbonylation provides an efficient and direct approach for the construction of valuable 1,3,4-oxadiazole-2(3H)-ones and their

Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4- oxadiazole-2(3H)-ones in water

It has been developed for the synthesis of substituted-1,3,4-oxadiazole- 2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields.

Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles

We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SnAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,

Fungicidal 5-oxo-4-trisubstituted tin-1,3,4-oxadiazolines

Compounds of the formula: STR1 wherein R is aryl of 6 to 10 carbon atoms; substituted aryl substituted with 1 to 5 substituents selected from halogen, nitro, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, lower alkylthio of 1 to