103729-18-6

Basic information

• Product Name: 3-(2-bromophenyl)octahydroindolizine
• Synonyms: 3-(2-bromophenyl)octahydroindolizine
• CAS NO: 103729-18-6
• Molecular Formula: C14H18 Br N
• Molecular Weight: 0
• Mol File: 103729-18-6.mol

Chemical Properties

• Boiling Point: 328.3°Cat760mmHg
• Flash Point: 152.4°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 3-(2-bromophenyl)octahydroindolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-bromophenyl)octahydroindolizine(103729-18-6)
• EPA Substance Registry System: 3-(2-bromophenyl)octahydroindolizine(103729-18-6)

Safety Data

• Hazardous Substances Data: 103729-18-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H18BrN/c15-13-7-2-1-6-12(13)14-9-8-11-5-3-4-10-16(11)14/h1-2,6-7,11,14H,3-5,8-10H2

Upstream product

• 2142-69-0 2-bromophenyl methyl ketone 
• 1121-60-4 pyridine-2-carbaldehyde 
• 104061-74-7 1-(2-bromophenyl)-3-(2-pyridinyl)-2-propen-1-one 

Relevant articles and documents

Catalytic Asymmetric Synthesis of Chiral γ-Amino Ketones via Umpolung Reactions of Imines

The first direct catalytic asymmetric synthesis of γ-amino ketones was realized by the development of a highly diastereoselective and enantioselective C-C bond-forming umpolung reaction of imines and enones under the catalysis of a new cinchona alkaloid-derived phase-transfer catalyst. In a loading ranging from 0.02 to 2.5 mol %, the catalyst activates a broad range of trifluoromethyl imines and aldimines as nucleophiles to engage in chemo-, regio-, diastereo- and enantioselective C-C bond-forming reactions with acyclic and cyclic enones, thereby converting these readily available prochiral starting materials into highly enantiomerically enriched chiral γ-amino ketones in synthetically useful yields. Enabled by this unprecedented umpolung reaction of imines, conceptually new and concise routes were developed for the asymmetric synthesis of nitrogen-heterocycles such as pyrrolidines and indolizidines.

2-Substituted 1-Azabicycloalkanes, a New Class of Non-Opiate Antinociceptive Agents

2-Substituted 1-azabicycloalkanes (3- and 5-aryloctahydroindolizines 2 and 11, 3-cyclohexyloctahydroindolizine 12, 4-aryloctahydroquinolizines 13, and 3-arylhexahydropyrrolizines 14) constitute a new class of non-opiate antinociceptive agents.These compou

3-diphenyl substituted octahydroindolizine analgesic compounds

Octahydroindolizine compounds of formula (I): STR1 wherein Q is --NR--, --(CH2)z --, --CH=CH--, --C C--, --OCH2 --, --SCH2 --, --SO2 --, --SO--, --CO--, or an oxygen or a sulfur atom and where R, R1 and R2 are substituents such as alkyl and x, y and z are independently the integers 0-3. Also, pharmaceutical compositions containing (I), intermediates and methods for treating pain.

Octahydroindolizine compounds useful as analgesics

Octahydroindolizidines of the formula (I): STR1 where A is a 3-7 carbon or hetero-containing ring, R1 is a substituent and x is 0-3. Also, pharmaceutical composition for treating pain and methods for synthesis and use as well as novel intermedi