103729-18-6Relevant articles and documents
Catalytic Asymmetric Synthesis of Chiral γ-Amino Ketones via Umpolung Reactions of Imines
Hu, Lin,Wu, Yongwei,Li, Zhe,Deng, Li
, p. 15817 - 15820 (2016)
The first direct catalytic asymmetric synthesis of γ-amino ketones was realized by the development of a highly diastereoselective and enantioselective C-C bond-forming umpolung reaction of imines and enones under the catalysis of a new cinchona alkaloid-derived phase-transfer catalyst. In a loading ranging from 0.02 to 2.5 mol %, the catalyst activates a broad range of trifluoromethyl imines and aldimines as nucleophiles to engage in chemo-, regio-, diastereo- and enantioselective C-C bond-forming reactions with acyclic and cyclic enones, thereby converting these readily available prochiral starting materials into highly enantiomerically enriched chiral γ-amino ketones in synthetically useful yields. Enabled by this unprecedented umpolung reaction of imines, conceptually new and concise routes were developed for the asymmetric synthesis of nitrogen-heterocycles such as pyrrolidines and indolizidines.
2-Substituted 1-Azabicycloalkanes, a New Class of Non-Opiate Antinociceptive Agents
Carson, John R.,Carmosin, Richard J.,Vaught, Jeffry L.,Gardocki, Joseph F.,Costanzo, Michael J.,et al.
, p. 2855 - 2863 (2007/10/02)
2-Substituted 1-azabicycloalkanes (3- and 5-aryloctahydroindolizines 2 and 11, 3-cyclohexyloctahydroindolizine 12, 4-aryloctahydroquinolizines 13, and 3-arylhexahydropyrrolizines 14) constitute a new class of non-opiate antinociceptive agents.These compou
3-diphenyl substituted octahydroindolizine analgesic compounds
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, (2008/06/13)
Octahydroindolizine compounds of formula (I): STR1 wherein Q is --NR--, --(CH2)z --, --CH=CH--, --C C--, --OCH2 --, --SCH2 --, --SO2 --, --SO--, --CO--, or an oxygen or a sulfur atom and where R, R1 and R2 are substituents such as alkyl and x, y and z are independently the integers 0-3. Also, pharmaceutical compositions containing (I), intermediates and methods for treating pain.
Octahydroindolizine compounds useful as analgesics
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, (2008/06/13)
Octahydroindolizidines of the formula (I): STR1 where A is a 3-7 carbon or hetero-containing ring, R1 is a substituent and x is 0-3. Also, pharmaceutical composition for treating pain and methods for synthesis and use as well as novel intermedi