1037840-79-1Relevant articles and documents
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist
Hoashi, Yasutaka,Takai, Takafumi,Kosugi, Yohei,Nakashima, Masato,Nakayama, Masaharu,Hirai, Keisuke,Uchikawa, Osamu,Koike, Tatsuki
, p. 3059 - 3074 (2021/04/06)
To develop potent and orally bioavailable melatonin receptor (MT1 and MT2) agonists, a novel series of 5-6-5 tricyclic derivatives was designed, synthesized, and evaluated. The synthesized indeno[5,4-d][1,3]oxazole, cyclopenta[c]pyrazolo[1,5-a]pyridine, i
HETEROCYCLIC COMPOUND
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, (2020/06/23)
Provided is a heterocyclic compound that can have an antagonistic action on an NMDA receptor containing the NR2B subunit, and is expected to be useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, periphera
BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 80, (2010/01/29)
The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 42, (2009/09/26)
The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group opt