103889-86-7

Basic information

• Product Name: (S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID
• Synonyms: (S)-2-METHOXY-PHENYLGLYCINE;(S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID
• CAS NO: 103889-86-7
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.19
• Product Categories: Unusual amino acids;pharmacetical
• Mol File: 103889-86-7.mol

Chemical Properties

• Boiling Point: 343.9 °C at 760 mmHg
• Flash Point: 161.8 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 2.6E-05mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID(103889-86-7)
• EPA Substance Registry System: (S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID(103889-86-7)

Safety Data

• Hazardous Substances Data: 103889-86-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to be asymmetrically synthesized, allowing for the creation of specific enantiomers with desired biological activities.
Used in Chemical Synthesis:
In the field of chemical synthesis, (S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID serves as a key building block for the development of novel molecules with potential applications in various industries, including materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
(S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID is utilized as a research compound for studying its properties and potential applications in different fields. Its unique structure and synthetic accessibility make it an attractive candidate for exploring new reactions and developing innovative chemical processes.
Used in Chiral Pool Synthesis:
As a homochiral α-arylglycine, (S)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID is used in chiral pool synthesis, a strategy that involves the use of chiral compounds as starting materials to create enantiomerically pure products. This application is particularly relevant in the development of enantiomerically pure drugs, which can have significant implications for their safety and efficacy.

InChI:InChI=1/C9H11NO3/c1-13-7-5-3-2-4-6(7)8(10)9(11)12/h2-5,8H,10H2,1H3,(H,11,12)/t8-/m0/s1

Upstream product

• 77651-54-8 5-(2-methoxyphenyl)imidazolidine-2,4-dione 
• 271583-23-4 2-(benzylamino)-2-(2-methoxyphenyl)acetic acid 
• 77651-55-9 2-methoxy phenylglycine methyl ester 
• 135-02-4 ortho-anisaldehyde 
• 58369-59-8 2-methoxy-α-(trichloromethyl)benzyl alcohol 
• 339274-27-0 (R)-2,2,2-trichloro-1-(2-methoxyphenyl)ethanol 
• 284687-65-6 2,2,2-trichloro-1-(2-methoxyphenyl)ethanone 
• 271583-39-2 2-(benzylamino)-2-(2-methoxyphenyl)acetamide 
• 271583-59-6 2-(benzylamino)-2-(2-methoxyphenyl)acetonitrile 

Downstream Products

• 77651-57-1 (2-Methoxy-phenyl)-methylsulfanylmethyleneamino-acetic acid methyl ester 
• 77651-56-0 methyl (+/-)-2-methoxy-α-<(thioxomethyl)amino>benzene acetate 

Relevant articles and documents

ISOINDOLIN-1-ON DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT FOR PREVENTING OR TREATING CANCER

The present invention relates to an isoindolin-1-one derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer, wherein the isoindolin-1-one derivative exhib

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

A practical asymmetric synthesis of homochiral α-arylglycines

Enantioselective reduction of a series of substituted aryl trichloromethyl ketones with the CBS-catecholborane reagent afforded homochiral aryl trichloromethyl carbinols which have been elaborated to give homochiral α-arylglycines in high e.e.

A facile synthesis of substituted phenylglycines

A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.