104271-41-2

Basic information

• Product Name: CYCLOPROPYL 3-METHOXYPHENYL KETONE
• Synonyms: CYCLOPROPYL 3-METHOXYPHENYL KETONE;cyclopropyl(3-Methoxyphenyl)Methanone
• CAS NO: 104271-41-2
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 104271-41-2.mol

Chemical Properties

• Boiling Point: 275.5°C at 760 mmHg
• Flash Point: 119.7°C
• Appearance: /
• Density: 1.142g/cm³
• Vapor Pressure: 0.00507mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: CYCLOPROPYL 3-METHOXYPHENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPYL 3-METHOXYPHENYL KETONE(104271-41-2)
• EPA Substance Registry System: CYCLOPROPYL 3-METHOXYPHENYL KETONE(104271-41-2)

Safety Data

• Hazardous Substances Data: 104271-41-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
CYCLOPROPYL 3-METHOXYPHENYL KETONE is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its reactivity and structural features make it instrumental in creating new drugs and biologically active molecules, contributing to advancements in medicinal chemistry.
Used in Organic Compound Synthesis:
This ketone is also employed in the synthesis of a variety of organic compounds, showcasing its versatility as a building block in organic chemistry.
Used in Fragrance and Flavor Production:
CYCLOPROPYL 3-METHOXYPHENYL KETONE serves as an intermediate in the production of fragrances and flavors, capitalizing on its chemical properties to create a diverse array of scent and taste profiles.
Used in Agrochemical Production:
Furthermore, this compound is used as an intermediate in the manufacture of agrochemicals, highlighting its broad application across different industries.

InChI:InChI=1/C11H12O2/c1-13-10-4-2-3-9(7-10)11(12)8-5-6-8/h2-4,7-8H,5-6H2,1H3

Upstream product

• 23719-80-4 cyclopropylmagnesium bromide 
• 152121-82-9 N,3‐dimethoxy‐N‐methylbenzamide 
• 586-38-9 3-Methoxybenzoic acid 
• 100-66-3 methoxybenzene 
• 5500-21-0 cyclopropropanecarbonitrile 
• 76106-47-3 cyclopropyl (3-hydroxyphenyl)methanone 
• 74-88-4 methyl iodide 

Downstream Products

• 104271-42-3 5,6-dihydro-8-(3-hydroxyphenyl)imidazo<1,2-a>pyridine 
• 104271-40-1 5,6-dihydro-8-(3-methoxyphenyl)imidazo<1,2-a>pyridine 
• 1355648-54-2 C₁₅H₁₈O₂ 

Relevant articles and documents

Regioselective, directed meta acylation of aromatic compounds

A new method for the directed meta acylation of aromatic compounds is described. This method involves an ortho lithiation procedure combined with zirconocene-benzyne chemistry. 3-Acyl-1-substituted benzene derivatives were obtained by acidic hydrolysis of the azazirconacycle intermediate which results from the coupling of a nitrile with a zirconocene-benzyne complex. Similarly, 3-acyl-2-iodo-1-substituted benzene derivatives were obtained by the iodination of the same intermediate followed by acidic hydrolysis. These procedures, which utilize simple, readily available starting materials, give good yields of regiochemically pure products.

TETRAZOLINONE COMPOUND AND USE THEREOF

A tetrazolinone compound represented by formula (1): wherein R1 and R2 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R3 represents a C1-C3 alkyl group optionally having one or more halogen atoms; R4, R5, and R6 each represents a hydrogen atom or a halogen atom; R7 represents a C1-C3 alkyl group; Q represents a divalent group selected from Group P4; and A represents a C7-C18 aralkyloxy group optionally having one or more atoms or groups selected from Group P3, has excellent control activity against pests.

Reactions of Aryl Cyclopropyl Ketones. A New Synthesis of Aryl Tetralones

Aryl cyclopropyl ketones (2) cyclise to 1-tetralones (3) in the presence of a variety of acid catalysts under mild conditions.Open-chain carbinols (4) are also formed.The ratio of (3) to (4) is dependent on the aryl ring substituents.A cationic mechanism is proposed.Cyclopropyl ketones (1) do not react.Stereoelectronic factors involved in the reactivity of the rigig cyclopropyl ketone (12) are discussed.The reactions of selected phenolic cyclopropyl ketones have been investigated as anionic counterparts to the acid-catalysed reactions.No reaction is observed.