104326-73-0Relevant articles and documents
Rapid screening of flonicamid residues in environmental and agricultural samples by a sensitive enzyme immunoassay
Liu, Zhenjiang,Zhang, Zhen,Zhu, Gangbing,Sun, Jianfan,Zou, Bin,Li, Ming,Wang, Jiagao
, p. 484 - 488 (2016)
A fast and sensitive polyclonal antibody-based enzyme-linked immunosorbent assay (ELISA) was developed for the analysis of flonicamid in environmental and agricultural samples. Two haptens of flonicamid differing in spacer arm length were synthesized and conjugated to proteins to be used as immunogens for the production of polyclonal antibodies. To obtain most sensitive combination of antibody/coating antigen, two antibodies were separately screened by homologous and heterologous assays. After optimization, the flonicamid ELISA showed that the 50% inhibitory concentration (IC50 value) was 3.86 mg L-1, and the limit of detection (IC20 value) was 0.032 mg L-1. There was no cross-reactivity to similar tested compounds. The recoveries obtained after the addition of standard flonicamid to the samples, including water, soil, carrot, apple and tomato, ranged from 79.3% to 116.4%. Moreover, the results of the ELISA for the spiked samples were largely consistent with the gas chromatography (R2 = 0.9891). The data showed that the proposed ELISA is an alternative tool for rapid, sensitive and accurate monitoring of flonicamid in environmental and agricultural samples.
Flonicamid synthesis method
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, (2017/10/07)
The invention discloses a flonicamid synthesis method, which comprises: synthesizing 4-trifluoromethylnicotinic acid; synthesizing 4-trifluoromethylnicotinyl chloride; synthesizing N-(chloromethyl)-N-(cyanomethyl)-4-trifluoromethylpyridine-3-carboxamide; carrying out heating reflux on the 4-trifluoromethylnicotinyl chloride, methylenaminoacetonitrile and toluene, carrying out pressure reducing toluene removal to obtain a N-(chloromethyl)-N-(cyanomethyl)-4-trifluoromethylpyridine-3-carboxamide crude product, and refining the crude product to obtain N-(hydroxymethyl)-N-(cyanomethyl)-4-trifluoromethylpyridine-3-carboxamide; and synthesizing flonicamid, wherein the N-(hydroxymethyl)-N-(cyanomethyl)-4-trifluoromethylpyridine-3-carboxamide is cooled, a sodium carbonate aqueous solution is added, stirring is performed at a room temperature, and filtration is performed to obtain a solid, ie., flonicamid. According to the present invention, the synthesis method has advantages of high yield, simple operation and high product purity, and is suitable for industrial production.
TRIFLUOROMETHYLPYRIDINE CARBOXAMIDES AS PESTICIDES
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Page/Page column 103, (2014/03/21)
Compounds of the formula I (I) wherein the substituent is as defined in claim 1, are useful as a pesticides.
PYRIDINE CARBOXAMIDE PESTICIDES
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Page/Page column 103, (2013/09/12)
Compounds of the formula (I), wherein the substituent R is as defined in claim 1, are useful as a pesticides.
CHEMICAL COMPOUNDS
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Page/Page column 101, (2013/09/12)
Compounds of the formula (I), wherein the substituent is as defined in claim 1, are useful as a pesticides.
Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides
Yonetoku, Yasuhiro,Kubota, Hirokazu,Miyazaki, Yoji,Okamoto, Yoshinori,Funatsu, Masashi,Yoshimura-Ishikawa, Noriko,Ishikawa, Jun,Yoshino, Taiji,Takeuchi, Makoto,Ohta, Mitsuaki
experimental part, p. 9457 - 9466 (2009/04/07)
From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC50 = 77 nM) and exhibited high selectivity for the CRAC channel over the VOC channel (index: >130). Another acted as an inhibitor for both T lymphocyte activation-induced diseases and ovalbumin-induced airway eosinophilia in rats (ED50 = 1.3 mg/kg) p.o.
3-PYRIDYLCARBOXAMIDE DERIVATIVES AS PESTICIDAL AGENTS
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Page 23-24, (2010/02/10)
The invention relates to a 3- pyridylcarboxamide derivative of formula (I): wherein the various symbols are as defined in the description, to compositions thereof, to their use for the control of pests, and to processes for their preparation.
AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE
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Page/Page column 88-92, (2010/02/14)
Azinyl imidazoazines of formula (I), in which the symbols have the meanings indicated in the description, are disclosed, as well as their salts and N oxides, processes for producing the same and new intermediate products. The use of the compounds of formula I and of the intermediate products for combating animal pests and undesirable micro-organisms is also disclosed.
N-HETEROARYLNICOTINAMIDE DERIVATIVES
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Page 41, (2008/06/13)
An N-heteroaryl-4-(haloalkyl)nicotinamide derivative represented by formula (I): [wherein R represents a C1-C6 haloalkyl group; R1 represents a hydrogen atom, a C1-C6 alkyl group which may be substituted a C2-C6 alkenyl group or an acyl group; X represents a group represented by formula C-R2, or a nitrogen atom; R2 and R3 each independently represent a hydrogen atom, a halogen atom, a C1-C6 alkyl group which may be substituted, a C3-C7 cycloalkyl group, a C2-C6 alkenyl group, a C3-C7 cycloalkenyl group, a formyl group, a group represented by formula CH=NOR4, a cyano group, a phenyl group which may be substituted, a heterocyclic group which may be substituted, a C1-C6 alkoxy group which may be substituted, a C1-C6 alkylthio group or a phenoxy group]; or a salt thereof, a pesticide containing it as an active component, a method for producing it and intermediates thereof.
Trifluoromethylpyri(mi)dine carboxamides
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, (2008/06/13)
Compounds of formula are described, along with a method of producing pesticidal compositions and the use of these compounds as pesticides.
