1044664-24-5

Basic information

• Product Name: 3-O-Acetyl Ezetimibe
• Synonyms: 3-O-Acetyl Ezetimibe;(3R,4S)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-2-azetidinone;Ezetimibe 3-O-Acetyl Impurity;(3S,4R)-rel-3-[(3R)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-2-azetidinone
• CAS NO: 1044664-24-5
• Molecular Formula: C26H23F2NO4
• Molecular Weight: 451.4619264
• Product Categories: Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1044664-24-5.mol

Chemical Properties

• Boiling Point: 643.414 °C at 760 mmHg
• Flash Point: 342.924 °C
• Appearance: /
• Density: 1.306 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, DMSO, Methanol
• CAS DataBase Reference: 3-O-Acetyl Ezetimibe(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-Acetyl Ezetimibe(1044664-24-5)
• EPA Substance Registry System: 3-O-Acetyl Ezetimibe(1044664-24-5)

Safety Data

• Hazardous Substances Data: 1044664-24-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-O-Acetyl ezetimibe is used as a pharmaceutical agent for its antihyperlipoproteinemic properties, which help in managing and treating conditions related to high levels of lipoproteins in the blood. Its ability to regulate lipid metabolism makes it a potential candidate for the development of drugs targeting hyperlipidemia and associated cardiovascular diseases.
Used in Drug Development:
In the field of drug development, 3-O-Acetyl ezetimibe serves as a key compound for research and development of new medications. Its unique chemical properties and therapeutic potential allow scientists to explore its efficacy in treating various lipid-related disorders and to improve upon its pharmacokinetic and pharmacodynamic profiles for better patient outcomes.
Used in Chemical Research:
3-O-Acetyl ezetimibe is also utilized in chemical research for studying the structure-activity relationships of 2-azetidinone derivatives. Understanding how its chemical structure influences its biological activity can lead to the design and synthesis of more effective and safer drugs with similar or improved properties.

Upstream product

• 163380-20-9 4(S)-(4-acetyloxyphenyl)-3(R)-(3(S)-acetyloxy-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-2-azetidinone 

Relevant articles and documents

An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption

Giving cholesterol the brush off: An intestinal brush border membrane vesicle assay has been devised for the convenient in vitro testing of small molecules for inhibition of cholesterol absorption. The assay was used to identify new nonhydrolyzable glycosides as potent cholesterol-absorption inhibitors and an oxazolidinone as an effective replacement of the β-lactam scaffold of ezetimibe (1).

Sugar-Substituted 2-Azetidinone Cholesterol Absorption Inhibitors: Enhanced Potency by Modification of the Sugar

A glucuronide conjugate of the potent 2-azetidinone cholesterol absorbtion inhibitor Sch 58235 was synthesized to confirm the structure of a metabolite isolated from in vivo sources.A series of 2-azetidinone glycosides was prepared via Schmidt trichloroim