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Pyrazolo[1,5-a]pyridine-5-carboxylic acid is a heterocyclic compound characterized by the fusion of a pyrazole ring with a pyridine ring, featuring a carboxylic acid group attached to the fifth carbon atom of the pyridine. This unique structural configuration endows it with potential biological activities and makes it a valuable building block in the synthesis of pharmaceuticals and agrochemicals.

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  • 104468-87-3 Structure
  • Basic information

    1. Product Name: pyrazolo[1,5-a]pyridine-5-carboxylic acid
    2. Synonyms: pyrazolo[1,5-a]pyridine-5-carboxylic acid;EOS-61211
    3. CAS NO:104468-87-3
    4. Molecular Formula: C8H6N2O2
    5. Molecular Weight: 162.14544
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 104468-87-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.41±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: -0.03±0.41(Predicted)
    10. CAS DataBase Reference: pyrazolo[1,5-a]pyridine-5-carboxylic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: pyrazolo[1,5-a]pyridine-5-carboxylic acid(104468-87-3)
    12. EPA Substance Registry System: pyrazolo[1,5-a]pyridine-5-carboxylic acid(104468-87-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 104468-87-3(Hazardous Substances Data)

104468-87-3 Usage

Uses

Used in Pharmaceutical Industry:
Pyrazolo[1,5-a]pyridine-5-carboxylic acid serves as a key intermediate in the development of novel compounds for medicinal purposes. Its unique structure and potential biological activities, including anti-inflammatory and antiviral properties, make it a promising candidate for the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, Pyrazolo[1,5-a]pyridine-5-carboxylic acid is utilized as a building block for the synthesis of new agrochemicals. Its versatile chemical structure allows for the creation of compounds with potential applications in pest control and crop protection, contributing to more effective and sustainable agricultural practices.

Check Digit Verification of cas no

The CAS Registry Mumber 104468-87-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,4,6 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 104468-87:
(8*1)+(7*0)+(6*4)+(5*4)+(4*6)+(3*8)+(2*8)+(1*7)=123
123 % 10 = 3
So 104468-87-3 is a valid CAS Registry Number.

104468-87-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Pyrazolo[1,5-a]pyridine-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104468-87-3 SDS

104468-87-3Relevant articles and documents

Interactive SAR studies: Rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists

Bettinetti, Laura,Schlotter, Karin,Hübner, Harald,Gmeiner, Peter

, p. 4594 - 4597 (2002)

Starting from dopamine receptor ligand BP897, an interactive drug discovery process leading to heterocyclic bioisosteres is demonstrated. The four step strategy involved a careful optimization of geometric and electronic properties by systematic modificat

NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES

-

Page/Page column 18; 19, (2018/03/26)

The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R5 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.

NITROGENATED HETEROCYCLIC COMPOUND

-

Paragraph 1023, (2015/03/28)

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

-

, (2014/06/11)

The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

-

, (2013/09/12)

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

-

, (2013/09/12)

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

AMIDO-BENZYL SULFOXIDE DERIVATIVES

-

, (2013/09/12)

The present invention relates to certain amido-benzyl sulfoxide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment of an NAMPT-mediated disease or condition in a subject, selected from solid or liquid tumor, rheumat

ALKYL-AND DI-SUBSTITUTED AMIDO-BENZYL SULFONAMIDE DERIVATIVES

-

, (2013/09/12)

The present invention relates to certain alkyl- and di-substituted amido-benzyl sulfonamide compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment of NAMPT-mediated disorders, such as diabetes, rheumatoid arthritis,

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

Kendall, Jackie D.,O'Connor, Patrick D.,Marshall, Andrew J.,Frédérick, Rapha?l,Marshall, Elaine S.,Lill, Claire L.,Lee, Woo-Jeong,Kolekar, Sharada,Chao, Mindy,Malik, Alisha,Yu, Shuqiao,Chaussade, Claire,Buchanan, Christina,Rewcastle, Gordon W.,Baguley, Bruce C.,Flanagan, Jack U.,Jamieson, Stephen M.F.,Denny, William A.,Shepherd, Peter R.

, p. 69 - 85 (2012/03/08)

We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.

PYRAZOLO[1,5-A]PYRIDINES AND THEIR USE IN CANCER THERAPY

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Page/Page column 43; 59-60, (2009/03/07)

Pyrazolo[1,5-a]pyridines are described, including methods for their preparation, and their use as agents or drugs for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

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