104774-88-1

Basic information

• Product Name: 4-(3-FLUORO-PHENYL)-PIPERIDINE
• Synonyms: 4-(3-FLUORO-PHENYL)-PIPERIDINE;Piperidine, 4-(3-fluorophenyl)-
• CAS NO: 104774-88-1
• Molecular Formula: C₁₁H₁₄FN
• Molecular Weight: 179.23
• Mol File: 104774-88-1.mol

Chemical Properties

• Boiling Point: 256℃
• Flash Point: 108℃
• Appearance: Gray-white power
• Density: 1.048
• Vapor Pressure: 0.0163mmHg at 25°C
• Refractive Index: 1.506
• PKA: 10.12±0.10(Predicted)
• CAS DataBase Reference: 4-(3-FLUORO-PHENYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-FLUORO-PHENYL)-PIPERIDINE(104774-88-1)
• EPA Substance Registry System: 4-(3-FLUORO-PHENYL)-PIPERIDINE(104774-88-1)

Safety Data

• Hazard Codes: Xi
• Statements: 52
• HazardClass: IRRITANT
• Hazardous Substances Data: 104774-88-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-Fluoro-phenyl)-piperidine is used as a synthetic intermediate for the development of new pharmaceuticals. The presence of the fluorine atom and the piperidine ring structure can contribute to the compound's biological activity, making it a promising candidate for the creation of novel drugs with improved efficacy and selectivity.
Used in Polymer Industry:
4-(3-Fluoro-phenyl)-piperidine is used as a monomer or a building block in the synthesis of polymers with specific properties. The fluorine atom and the piperidine ring can impart unique characteristics to the resulting polymers, such as enhanced thermal stability, improved mechanical properties, or increased chemical resistance.
Used in Fine Chemicals Industry:
4-(3-Fluoro-phenyl)-piperidine is used as a key component in the production of fine chemicals, such as agrochemicals, fragrances, and dyes. 4-(3-Fluoro-phenyl)-piperidine's unique structure and properties can be exploited to create specialized products with tailored performance characteristics, such as increased stability, enhanced reactivity, or improved solubility.

InChI:InChI=1/C11H14FN/c12-11-3-1-2-10(8-11)9-4-6-13-7-5-9/h1-3,8-9,13H,4-7H2

Upstream product

• 694-05-3 1,2,3,6-tetrahydropyridine 
• 462-06-6 fluorobenzene 
• 1086398-00-6 tert-butyl 4-(3-fluorophenyl)piperidine-1-carboxylate 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 768-35-4 3-fluorophenylboronic acid 
• 358722-19-7 4-(3-fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 107336-12-9 2-{3-[4-(3-Fluoro-phenyl)-piperidin-1-yl]-propoxy}-benzaldehyde 
• 107335-80-8 2-(2-{2-[4-(3-Fluoro-phenyl)-piperidin-1-yl]-ethoxy}-phenyl)-thiazolidine-3-carbothioic acid methylamide 
• 107335-85-3 2-(2-{3-[4-(3-Fluoro-phenyl)-piperidin-1-yl]-propoxy}-phenyl)-thiazolidine-3-carbothioic acid methylamide 
• 1254948-78-1 C₁₇H₁₅F₇N₂OS 

Relevant articles and documents

Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents

Epilepsy is a kind of disease with complicated pathogenesis. KCNQ (Kv7) is a voltage dependent potassium channel that is mostly associated with epilepsy and thus becomes an important target in the treatment of epilepsy. In this paper, a series of substituted piperidine derivatives targeting KCNQ were designed and synthesized by using scaffold hopping and active substructure hybridization. Compounds were evaluated by fluorescence-based thallium influx assay, Rb+ flow assay and electrophysiological patch-clamp assay. Results showed that some compounds possessed more potent potassium channel opening activity than Retigabine. More significantly, compound 11 was found to have good pharmacokinetic profiles in vivo.

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.

Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists

This report describes replacement of the 4-(4-fluorophenyl)piperidine moiety in our CCR2 antagonists with 4-heteroaryl piperidine and 4-(carboxyphenyl)-piperidine subunits. Some of the resulting analogs retained potency in our CCR2 binding assay and had i

Superacid-catalyzed preparation of aryl-substituted piperidines via dicationic electrophiles

The electrophilic chemistry of 1,2,3,6-tetrahydropyridines has been studied in the Bronsted superacid, CF3SO3H (triflic acid). The 1,2,3,6-tetrahydropyridines react with arenes to give aryl-substituted piperidines. It is proposed tha