104819-48-9

Basic information

• Product Name: 2-BROMO-3-METHOXYPYRIDINE-N-OXIDE
• Synonyms: 2-BROMO-3-METHOXYPYRIDINE-N-OXIDE;2-bromo-3-methoxy-1-oxidopyridin-1-ium;Pyridine,2-bromo-3-methoxy-, 1-oxide
• CAS NO: 104819-48-9
• Molecular Formula: C₆H₆BrNO₂
• Molecular Weight: 204.02134
• Product Categories: Pyridine
• Mol File: 104819-48-9.mol

Chemical Properties

• Boiling Point: 360.9 °C at 760 mmHg
• Flash Point: 172.1 °C
• Appearance: /
• Density: 1.61 g/cm³
• Vapor Pressure: 4.46E-05mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 2-BROMO-3-METHOXYPYRIDINE-N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-METHOXYPYRIDINE-N-OXIDE(104819-48-9)
• EPA Substance Registry System: 2-BROMO-3-METHOXYPYRIDINE-N-OXIDE(104819-48-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 104819-48-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Bromo-3-Methoxypyridine-N-Oxide is used as a key intermediate in the development of antiviral and anti-inflammatory drugs due to its unique chemical structure and reactivity. Its presence in drug molecules can potentially enhance their therapeutic effects and target specific biological pathways.
Used in Organic Synthesis:
As a building block, 2-Bromo-3-Methoxypyridine-N-Oxide is employed in the synthesis of various heterocyclic compounds, which are essential in the creation of complex organic molecules with diverse applications in chemistry and biology.
Used in Laboratory Settings:
2-Bromo-3-Methoxypyridine-N-Oxide is used as a reagent in laboratory experiments, where its high reactivity is leveraged for specific chemical reactions. However, due to its potential health hazards, it is handled with caution and under appropriate safety measures.

InChI:InChI=1/C6H6BrNO2/c1-10-5-3-2-4-8(9)6(5)7/h2-4H,1H3

Upstream product

• 6602-28-4 3-hydroxypyridine N-oxide 
• 74-88-4 methyl iodide 
• 24100-18-3 2-bromo-3-methoxypyridine 
• 109-00-2 3-HYDROXYPYRIDINE 
• 6602-32-0 2-bromo-pyridin-3-ol 

Downstream Products

• 37338-80-0 3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide 
• 72016-31-0 orelline 
• 104819-52-5 2-bromo-3,4-dimethoxy pyridine 
• 101664-55-5 3,3',4,4'-tetramethoxy-2,2'-bipyridine 

Relevant articles and documents

NEW REACTIONS OF PYRIDINES AND TOTAL SYNTHESIS OF THE FUNGAL TOXIN ORELLANINE

Dihalogenated pyridines react easily with sulphur nucleophiles, in dipolar aprotic solvents (DMF), to afford the products of mono- or of bis-substitution depending on the experimental conditions.On the contrary, with oxygen nucleophiles the bis-substituted products can be obtained only with some particular substrates.A new and efficient procedure to effect the homo-coupling of halogenoarenes will be presented.This reaction, wich occurs under the influence of low-valent nickel complexes, allowed us to effect the total synthesis of Orellanine, the lethal toxin of Cortinarius orellanus mushroom, as well as the syntheses of its decompositionproducts Orellinine and Orelline.The chemical properties of these three products and their behaviour towards UV irradiation will be presented and discussed.