6602-28-4Relevant academic research and scientific papers
Method for synthesizing 3-hydroxy-2-picolinic acid and derivatives thereof
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Paragraph 0044-0045, (2020/12/31)
The invention discloses an effective synthesis method of 3-hydroxy-2-picolinic acid and derivatives thereof. The method comprises an oxidation reaction, a cyanation reaction and a hydrolysis reaction.According to the oxidation reaction, 3-hydroxypyridine as shown in a formula I and derivatives thereof are used as substrates, and under the condition that an aqueous hydrogen peroxide solution is used as an oxidizing agent, the reaction is performed in glacial acetic acid at 60 DEG C in a nitrogen environment to obtain an oxidation product as shown in a structural general formula II. According to the cyanation reaction, the compound II and trimethylsilyl cyanide are taken as substrates and mixed with dimethylaminoformyl chloride in an ice bath, and then the reaction is conducted in dichloromethane at room temperature in the nitrogen environment to obtain a cyanation product as shown in a structural general formula III. According to the hydrolysis reaction, with the product as shown in the formula III as a substrate, the reaction is conducted in ethanol at a temperature of 80 DEG C under the condition of an aqueous sodium hydroxide solution to obtain the 3-hydroxy-2-picolinic acid asshown in the structural general formula IV and the derivatives thereof. The method is relatively economical, reaction universality is good, gram-level preparation is easy to carry out, the whole process can be industrialized, and reaction conditions are green.
A lipase-glucose oxidase system for the efficient oxidation of: N -heteroaromatic compounds and tertiary amines
Yang, Fengjuan,Zhang, Xiaowen,Li, Fengxi,Wang, Zhi,Wang, Lei
supporting information, p. 3518 - 3521 (2016/07/06)
In this work, a lipase-glucose oxidase system has been designed and proven to be an efficient system for the oxidation of N-heteroaromatic compounds and tertiary amines. This dual-enzyme system not only displays environmental friendliness, but also demonstrates its huge potential in industrial applications.
Grafting of a rhenium-oxo complex on Schiff base functionalized graphene oxide: An efficient catalyst for the oxidation of amines
Khatri, Praveen K.,Choudhary, Shivani,Singh, Raghuvir,Jain, Suman L.,Khatri, Om P.
, p. 8054 - 8061 (2014/05/20)
A rhenium-oxo complex such as methyltrioxorhenium (MTO) has been homogeneously immobilized on a Schiff base modified graphene oxide (GrO) support via covalent bonding. The loading of MTO on GrO nanosheets was monitored by FTIR, TG-DTA, and elemental analyses. The developed heterogeneous catalyst is found to be efficient for the oxidation of various amines to the corresponding N-oxides using hydrogen peroxide as an oxidant in high to excellent yields. At the end of the reaction, the catalyst is readily recovered by filtration and reused for subsequent runs. After the third run, the catalyst showed a marginal decrease in catalytic activity owing to the leaching of the MTO complex from the support. This journal is the Partner Organisations 2014.
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
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Page/Page column 8-9, (2008/06/13)
Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and at least one N-oxides of six-membered rings with one or two nitrogen atoms keratin dyeing compound. A method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.
FURTHER FUNCTIONAL GROUP OXIDATIONS USING SODIUM PERBORATE
McKillop, Alexander,Kemp, Duncan
, p. 3299 - 3306 (2007/10/02)
Sodium perborate in acetic acid is an effective reagent for the oxidation of aromatic aldehydes to carboxylic acids, iodoarenes to (diacetoxyiodo)arenes, azines to N-oxides, and various types of sulfur heterocycles to S,S-dioxides.Nitriles are unaffected by the reagent in acetic acid, but undergo smooth hydration to amides when aqueous methanol is employed as solvent.
Pattern of Addition of Hydroxyl Radicals to the Spin Traps α-Pyridyl 1-Oxide N-tert-Butyl Nitrone
Neta, P.,Steenken, S.,Janzen, Edward G.,Shetty, Raghav V.
, p. 532 - 534 (2007/10/02)
Hydroxyl radicals react with α-2, α-3, and α-4-pyridyl 1-oxide N-tert-butyl nitrones (POBN) with rate constants of 3.2E9, 4.8E9, and 3.5E9 M-1 s-1, respectively, via addition to two distinct sites.Addition to the pyridine ring yields short-lived radicals of the hydroxyazacyclohexadienyl type, while addition to the nitrone function in the side chain yields long-lived nitroxide radicals.The distribution of OH addition at the two molecular sites was determined by using differences in reducing power upon reaction of the different types of radicals with IrCl62-.The fraction of OH attack on the pyridine ring is ca. 0.6, relatively independent of the isomeric structure of the POBN.
KINETICS OF THE N OXIDATION OF SOME COMPOUNDS OF THE PYRIDINE SERIES WITH PERBENZOIC ACID IN CHLOROFORM AND AQUEOUS DIOXANE
Lohkov, R.E.
, p. 264 - 271 (2007/10/02)
A comparative study of the kinetics of the N oxidation of 19 derivatives of the pyridine series with perbenzoic acid in choroform and aqueous dioxane at 20, 25, 30, and 35 deg C was made.The rate constants, the parameters of the Arrhenius equation, and the activation energies of the N oxidation of the indicated monoazines were determined.The scale of the reactivities of the derivatives of the pyridine series was calculated within the framework of the Pearson hard-soft acid-base concept.
