104864-59-7

Basic information

• Product Name: 2-CHLORO-N-{2-[(4-CHLOROPHENYL)THIO]ETHYL}ACETAMIDE
• Synonyms: 2-chloro-N-{2-[(4-chlorophenyl)sulfanyl]ethyl}acetamide
• CAS NO: 104864-59-7
• Molecular Formula: C₁₀H₁₁Cl₂NOS
• Molecular Weight: 264.17
• Mol File: 104864-59-7.mol

Chemical Properties

• Boiling Point: 447.9°Cat760mmHg
• Flash Point: 224.7°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 3.24E-08mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 2-CHLORO-N-{2-[(4-CHLOROPHENYL)THIO]ETHYL}ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-{2-[(4-CHLOROPHENYL)THIO]ETHYL}ACETAMIDE(104864-59-7)
• EPA Substance Registry System: 2-CHLORO-N-{2-[(4-CHLOROPHENYL)THIO]ETHYL}ACETAMIDE(104864-59-7)

Safety Data

• Hazardous Substances Data: 104864-59-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11Cl2NOS/c11-7-10(14)13-5-6-15-9-3-1-8(12)2-4-9/h1-4H,5-7H2,(H,13,14)

Upstream product

• 24194-09-0 2-(4-chloro-phenylsulfanyl)-ethylamine; hydrochloride 
• 79-04-9 chloroacetyl chloride 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 104864-22-4 N-(4-methyl-1-piperazinyl)acetyl-2-(p-chlorophenylthio)ethanamine hydrochloride 

Relevant articles and documents

2-(Arylthio)ethanamines and &α-(Arylthio)propionamides with Antidepressant Activity

Reaction of aziridine with thiophenols affords 2-arylthioethanamines; with 2-methylaziridine, ring opening occurs regiospecifically to provide 1-arylthio-2-propanamines.The structure of one member of this group, 1-(4-chlorophenylthio)-2-propanamine (7), has been proved by other unambiguous syntheses. 7 and isomer 12 arise from the alkylation of 4-chlorothiophenol with 2-chloropropylamine as well as from the displacement of the tosyl group in 1-(4-chlorophenylthio)-2-tosyloxypropane (13).Alkylation of 4-chlorothiophenol with α-chloropropionamide affords 11 which leads to 12 on LAH reduction.Ethanamines and propanamines are converted into guanidines, amides, ureas and thioureas.Many arylthioethanamines, e.g. 7, 22, 28, 38 and 39 (as HCl salts) and α-arylthiopropionamides, e.g. 11, 86, 91, 93 and 96 exhibit good activity in the DOPA potentiation and reserpine antagonism tests.Among these, 7 HCl is the most potent and does not inhibit rat brain MAO activity.In clinical trials, C 2998-Go compares favourably with imipramine.