Direct displacement of -OH by nucleophiles in hydroxymethylimidazoles
Direct displacement of -OH from 4- and 5-hydroxymethylimidazoles is achieved in good to excellent yields simply by heating a 4- or 5- hydroxymethylimidazole in the presence of an appropriate nucleophile in refluxing basic water. (C) 2000 Elsevier Science Ltd.
Macor, John E.,Cornelius, Lyndon A. M.,Roberge, Jacques Y.