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3,5-DIMETHOXYPHENYL ISOTHIOCYANATE is a chemical compound with the molecular formula C10H9NO2S, characterized as a derivative of isothiocyanate featuring a sulfur atom bonded to an isocyanate group. This yellowish solid is utilized in organic synthesis and serves as a precursor for the creation of various bioactive compounds. It has garnered interest for its potential antimicrobial and anticancer properties, as well as its capacity to modify proteins and peptides. Notably, 3,5-DIMETHOXYPHENYL ISOTHIOCYANATE is recognized for its strong, unpleasant odor and should be handled with care due to its potential irritant properties.

104968-58-3

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104968-58-3 Usage

Uses

Used in Organic Synthesis:
3,5-DIMETHOXYPHENYL ISOTHIOCYANATE is used as a building block in organic synthesis for the preparation of a variety of bioactive compounds, leveraging its unique chemical structure to create new molecules with potential applications in various fields.
Used in Pharmaceutical Research:
3,5-DIMETHOXYPHENYL ISOTHIOCYANATE is used as a research compound for exploring its antimicrobial and anticancer properties. Its potential to inhibit the growth of certain microbes and cancer cells makes it a valuable candidate for further investigation in the development of new therapeutic agents.
Used in Protein and Peptide Modification:
3,5-DIMETHOXYPHENYL ISOTHIOCYANATE is used as a modifying agent for proteins and peptides, capitalizing on its reactivity to alter the properties of these biomolecules. This modification can enhance their stability, activity, or introduce new functionalities, which is crucial in the fields of biotechnology and medicine.
Used in Chemical Education and Research:
3,5-DIMETHOXYPHENYL ISOTHIOCYANATE is utilized as an educational tool and research material in academic and research institutions, where it can be employed to study the properties of isothiocyanate derivatives and their reactions, contributing to the advancement of chemical knowledge and innovation.

Check Digit Verification of cas no

The CAS Registry Mumber 104968-58-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,9,6 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104968-58:
(8*1)+(7*0)+(6*4)+(5*9)+(4*6)+(3*8)+(2*5)+(1*8)=143
143 % 10 = 3
So 104968-58-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO2S/c1-11-8-3-7(10-6-13)4-9(5-8)12-2/h3-5H,1-2H3

104968-58-3 Well-known Company Product Price

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  • Alfa Aesar

  • (A15728)  3,5-Dimethoxyphenyl isothiocyanate, 97%   

  • 104968-58-3

  • 1g

  • 821.0CNY

  • Detail
  • Alfa Aesar

  • (A15728)  3,5-Dimethoxyphenyl isothiocyanate, 97%   

  • 104968-58-3

  • 5g

  • 3103.0CNY

  • Detail
  • Alfa Aesar

  • (A15728)  3,5-Dimethoxyphenyl isothiocyanate, 97%   

  • 104968-58-3

  • 25g

  • 13783.0CNY

  • Detail

104968-58-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-isothiocyanato-3,5-dimethoxybenzene

1.2 Other means of identification

Product number -
Other names 3,5-Dimethoxyphenyl isothiocyanate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104968-58-3 SDS

104968-58-3Relevant articles and documents

Synthesis of isothiocyanates using DMT/NMM/TsO? as a new desulfurization reagent

Janczewski, ?ukasz,Kolesińska, Beata,Kr?giel, Dorota

, (2021/05/29)

Thirty-three alkyl and aryl isothiocyanates, as well as isothiocyanate derivatives from esters of coded amino acids and from esters of unnatural amino acids (6-aminocaproic, 4-(aminomethyl)benzoic, and tranexamic acids), were synthesized with satisfactory or very good yields (25–97%). Synthesis was performed in a “one-pot”, two-step procedure, in the presence of organic base (Et3 N, DBU or NMM), and carbon disulfide via dithiocarbamates, with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate (DMT/NMM/TsO? ) as a desulfurization reagent. For the synthesis of aliphatic and aromatic isothiocyanates, reactions were carried out in a microwave reactor, and selected alkyl isothiocyanates were also synthesized in aqueous medium with high yields (72–96%). Isothiocyanate derivatives of L-and D-amino acid methyl esters were synthesized, under conditions without microwave radiation assistance, with low racemization (er 99 > 1), and their absolute configuration was confirmed by circular dichroism. Isothiocyanate derivatives of natural and unnatural amino acids were evaluated for antibacterial activity on E. coli and S. aureus bacterial strains, where the most active was ITC 9e.

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

Sun, Maolin,Xu, Qile,Xu, Jingwen,Wu, Yue,Wang, Yueting,Zuo, Daiying,Guan, Qi,Bao, Kai,Wang, Jian,Wu, Yingliang,Zhang, Weige

, (2017/04/01)

A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors and evaluated for their antiproliferative activity in three human cancer cell lines. Most of the target compounds displayed moderate antiproliferative activity, and N-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1,3-thiazol-2-amine (10s) was determined to be the most potent compound. Tubulin polymerization and immunostaining experiments revealed that 10s potently inhibited tubulin polymerization and disrupted tubulin microtubule dynamics in a manner similar to CA-4. Moreover, 10s effectively induced SGC-7901 cell cycle arrest at the G2/M phase in both concentrationand time-dependent manners. The molecular docking results revealed that 10s could bind to the colchicine binding site of tubulin.

Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods

Minegishi, Hidemitsu,Futamura, Yushi,Fukashiro, Shinji,Muroi, Makoto,Kawatani, Makoto,Osada, Hiroyuki,Nakamura, Hiroyuki

, p. 4230 - 4241 (2015/06/08)

A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to posse

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