16147-07-2Relevant academic research and scientific papers
Synthesis and initial biological evaluation of myxocoumarin B
Müller, Jonas I.,Kusserow, Kalina,Hertrampf, Gesa,Pavic, Aleksandar,Nikodinovic-Runic, Jasmina,Gulder, Tobias A. M.
, p. 1966 - 1969 (2019)
The myxocoumarins A and B from Stigmatella aurantiaca MYX-030 are natural products featuring unusual nitro- and long-chain alkyl substitution. While myxocoumarin A was shown to exhibit strong antifungal properties, the antifungal potential of myxocoumarin
Base promoted peroxide systems for the efficient synthesis of nitroarenes and benzamides
Gupta, Sampa,Ansari, Alisha,Sashidhara, Koneni V.
supporting information, (2019/09/07)
A useful and efficient approach for the synthesis of nitroarenes from several aromatic amines (including heterocycles) using peroxide and base has been developed. This oxidative reaction is very easy to handle and afforded the products in good yields. Formation of benzamides from benzylamine was also successfully carried out with this metal-free catalytic system in good to excellent yields.
Nucleophilic Nitration of Arynes by Sodium Nitrite and its Multicomponent Reaction Leading to Double-Functionalized Arenes
Dhokale, Ranjeet A.,Mhaske, Santosh B.
supporting information, p. 3010 - 3013 (2016/07/06)
An unusual nucleophilic nitration of arynes by NaNO2 in the presence of water has been developed, and the concept was further demonstrated to accomplish a double functionalization of arynes using a multicomponent reaction protocol to synthesize pharmaceutically important (2-nitrophenyl)methanol derivatives. Such substitution ortho to -NO2 is difficult by other means. The reaction conditions are mild and avoid the use of strong acids, expensive transition metal catalysts, and additives.
Pd-catalyzed conversion of aryl chlorides, triflates, and nonaflates to nitroaromatics
Fors, Brett P.,Buchwald, Stephen L.
supporting information; experimental part, p. 12898 - 12899 (2009/12/07)
(Chemical Equation Presented) An efficient Pd catalyst for the transformation of aryl chlorides, triflates, and nonaflates to nitroaromatics has been developed. This reaction proceeds under weakly basic conditions and displays a broad scope and excellent
LIGANDS FOR TRANSITION-METAL-CATALYZED CROSS-COUPLINGS, AND METHODS OF USE THEREOF
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Page/Page column 144-145, (2009/07/17)
Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition-metal-catalyzed cross-coupling reactions.
Nitration of electron-rich aromatic compounds by cerium ammonium nitrate coated on silica
Grenier, Jean-Luc,Catteau, Jean-Pierre,Cotelle, Philippe
, p. 1201 - 1208 (2007/10/03)
Treatment of electron-rich aromatic derivatives with cerium (IV) ammonium nitrate coated on silica (CANSio2) affords nitro aromatic compounds. The scope and the limitation of this reaction are discussed.
THE OXIDATION OF AROMATIC AMINES IN THE PRESENCE OF "ELECTRON-RICH" AROMATIC SYSTEMS
Zabrowsky, Daniel L.,Moormann, Alan E.,Beck, Kenneth R.
, p. 4501 - 4504 (2007/10/02)
The oxidation of aromatic amines to the corresponding nitro substituents is performed under mild, nonacidic conditions in the presence of highly nucleophilic aromatic systems such as indoles and furans.
