1055888-89-5

Basic information

• Product Name: Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98%
• Synonyms: Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98%;3-(Di-tert-butylphosphino)propane-1-sulfonic acid, 97%;3-(Di-tert-butylphosphoniuM)propane sulfonate;3-(Di-t-butylphosphoniuM)propane sulfonate, 97% (DTBPPS);Di-t-butyl(3-sulfonatopropyl)phosphineDi-t-butyl(3-sulfonatopropyl)phosphine;3-[Bis(1,1-dimethylethyl)phosphino]-1-propanesulfonic acid;Di-t-butyl(3-sulfonatopropyl)phosphine;3-(Di-t-butylphosphonium)propane sulfonate
• CAS NO: 1055888-89-5
• Molecular Formula: C₁₁H₂₅O₃PS
• Molecular Weight: 268.353161
• Product Categories: Achiral Phosphine;Alkyl Phosphine
• Mol File: 1055888-89-5.mol

Chemical Properties

• Appearance: white/solid
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.79±0.50(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98%(CAS DataBase Reference)
• NIST Chemistry Reference: Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98%(1055888-89-5)
• EPA Substance Registry System: Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98%(1055888-89-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• TSCA: No
• Hazardous Substances Data: 1055888-89-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98% is used as a ligand in the pharmaceutical industry for enhancing the efficiency and selectivity of palladium-catalyzed cross-coupling reactions. This leads to the synthesis of complex molecules and pharmaceutical compounds with improved properties and reduced side effects.
Used in Chemical Research:
In the field of chemical research, Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98% is used as a ligand for conducting palladium-catalyzed cross-coupling reactions. This allows researchers to explore new reaction pathways, develop innovative synthetic methods, and create novel compounds with potential applications in various industries.
Used in Material Science:
Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98% is used as a ligand in material science for the synthesis of advanced materials with specific properties. The use of this ligand in palladium-catalyzed cross-coupling reactions enables the creation of materials with tailored characteristics, such as improved mechanical strength, thermal stability, or electrical conductivity.
Overall, Di-t-butyl(3-sulfonatopropyl)phosphine, min. 98% is a versatile and valuable compound in various industries, including pharmaceuticals, chemical research, and material science, due to its role as an air stable, water-soluble phosphine ligand in palladium-catalyzed cross-coupling reactions.

Upstream product

• 1120-71-4 1,3-propanesultone 
• 819-19-2 di-tert-butylphosphine 

Relevant articles and documents

Anthracene-Bodipy dyads as fluorescent sensors for biocatalytic diels alder reactions

Fluorescence spectroscopy is a powerful, extremely sensitive technique for the investigation of enzyme and ribozyme mechanisms. Herein, we describe the synthesis and characterization of water-soluble fluorescence probes for studying biocatalytic Diels-Alder reactions. These probes consist of anthracene and sulfonated BODIPY fluorophores fused by conjugated phenylacetylenyl bridges. Intact anthracene efficiently quenches BODIPY fluorescence, likely by photoinduced electron transfer. Upon destruction of the aromatic system by the Diels-Alder reaction, the fluorescence emission increases 20-fold. Binding in the catalytic pocket of a Diels-Alderase ribozyme yields a further ～2-fold increase in the fluorescence intensity of both the anthracene-BODIPY and the Diels-Alder-product-BODIPY probes. Therefore, a fluorescence-based distinction of free substrate, bound substrate, bound product, and free product is possible. With these all-in-one reporters, we monitored RNA-catalyzed Diels-Alder reactions under both single- and multiple-turnover conditions down to the nanomolar concentration range. Burst analysis at the single-molecule level revealed blinking of the dyads between an on state and an off state, presumably due to rotation around the phenylacetylenyl bridge. Binding to the ribozyme does not increase the intensity of the individual fluorescence bursts, but rather increases the average time spent in the on state. Variations in the quantum yields of the different probes correlate well with the degree of conjugation between anthracene and the phenylacetylenyl bridge.

Sterically demanding, zwitterionic trialkylphosphonium sulfonates as air-stable ligand precursors for efficient palladium-catalyzed cross-couplings of aryl bromides and chlorides

3-(Di-tert-butylphosphonium)propane sulfonate (DTB-PPS) and 3-(diadamantylphosphonium)propane sulfonate (DAPPS) are air-stable pre-ligands for aqueous-phase palladium-catalyzed cross-coupling reactions. Both DTBPPS and DAPPS were found to give active catalysts for the Sonogashira coupling of aryl bromides at room temperature and 4-chloroanisole at 80 °C. These ligands also gave effective catalysts for the aqueous-phase Suzuki coupling of aryl bromides at room temperature.