- Isoquinolines as urokinase inhibitors
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Compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N=C(NH2)2 or NHC(=NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors.
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- Substituted isoquinolinesulfonyl compounds
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An isoquinolinesulfonyl compound represented by the formula (I): STR1 wherein R1 : H, Cl, OH A : unsubstituted or substituted ethylene or alkylene R2, R3 : H, alkyl, jointly forming unsubstituted or substituted ethylene or trimethylene R4 : H, alkyl, amidino or an acid salt thereof. They can be prepared, for example, by converting 1-R1 substituted-5-isoquinolinesulfonic acid to the corresponding sulfonyl chloride and subsequently reacting the chloride with a compound of formula STR2 They can be advantageously utilized as vasodilator, cerebral circulation ameliorator, antihypertensive agent and drugs for prevention and treatment of various circulatory organ diseases.
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