141519-77-9

Basic information

• Product Name: 1-Chloro-5-isoquinolinesulfonyl Chloride
• Synonyms: 1-Chloro-5-isoquinolinesulfonyl Chloride;1-Chloroisoquinoline-5-sulfonyl Chloride;1-chloro-isoquinolin-5-sulfonyl chloride
• CAS NO: 141519-77-9
• Molecular Formula: C₉H₅Cl₂NO₂S
• Molecular Weight: 262.11
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Sulfonyl Chlorides
• Mol File: 141519-77-9.mol

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: 1-Chloro-5-isoquinolinesulfonyl Chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-5-isoquinolinesulfonyl Chloride(141519-77-9)
• EPA Substance Registry System: 1-Chloro-5-isoquinolinesulfonyl Chloride(141519-77-9)

Safety Data

• Hazardous Substances Data: 141519-77-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Chloro-5-isoquinolinesulfonyl Chloride is used as a reagent in organic synthesis for its ability to facilitate a range of chemical reactions. Its presence in the reaction mixture can enhance the formation of desired products, making it a crucial component in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Chloro-5-isoquinolinesulfonyl Chloride is used as an intermediate in the production of certain drugs. Its unique chemical structure allows it to be a key building block in the development of new medications, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Chemical Research:
1-Chloro-5-isoquinolinesulfonyl Chloride is also employed as a research tool in chemical laboratories. Its properties make it an interesting subject for studying various aspects of chemistry, such as reaction mechanisms, structural analysis, and the development of new synthetic methods.

Upstream product

• 105627-80-3 1-chloro-5-isoquinolinesulphonic acid 
• 7790-94-5 chlorosulfonic acid 
• 19493-44-8 1-chloroisoquinoline 

Downstream Products

• 787576-13-0 1-chloro-isoquinoline-5-sulfonic acid (2-{[3-(2-benzyl-4-chloro-phenoxy)-propyl]-[bis-(4-methoxy-phenyl)-methyl]-amino}-ethyl)-amide 
• 874447-87-7 (2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-hydroxyisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 874447-86-6 (2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-chloroisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 874447-84-4 (2S,4S)-2-(4-chlorobenzyloxymethyl)-4-(1-chloroisoquinoline-5-sulfonylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1155860-54-0 C₂₂H₂₀Cl₃N₃O₃S 

Relevant articles and documents

ROCK KINASE INHIBITORS

The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Structure-based drug design of novel isoquinoline-5-sulfonamide inhibitors of PKB as potential antitumour agents was investigated. Constrained pyrrolidine analogues that mimicked the bound conformation of linear prototypes were identified and investigated by co-crystal structure determinations with the related protein PKA. Detailed variation in the binding modes between inhibitors with similar overall conformations was observed. Potent PKB inhibitors from this series inhibited GSK3β phosphorylation in cellular assays, consistent with inhibition of PKB kinase activity in cells.

ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B)

The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.

Isoquinolines as urokinase inhibitors

Compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N=C(NH2)2 or NHC(=NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors.